Nick J Spencer
Overview
Explore the profile of Nick J Spencer including associated specialties, affiliations and a list of published articles.
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Articles
146
Citations
2329
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Recent Articles
1.
Humenick A, Chen B, Johnson M, Yew W, Wattchow D, Sia T, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Feb;
:101479.
PMID: 39978461
No abstract available.
2.
Wattchow D, Brookes S, Spencer N, De Giorgio R, Costa M, Dinning P
Neurogastroenterol Motil
. 2025 Jan;
e14995.
PMID: 39777822
Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways. In some cases, abnormalities in neural activity...
3.
Parkar N, Young W, Olson T, Hurst C, Janssen P, Spencer N, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684893
Although effects of stress-induced anxiety on the gastrointestinal tract and enteric nervous system (ENS) are well studied, how ENS dysfunction impacts behaviour is not well understood. We investigated whether ENS...
4.
Yew W, Hibberd T, Spencer N, Zagorodnyuk V
Auton Neurosci
. 2024 Dec;
256:103231.
PMID: 39627069
Piezo ion channels play a role in bladder sensation, but the sensory afferent subtypes that utilise Piezo channels have not been fully explored. We made single-unit extracellular recordings from mucosal-projecting...
5.
Parkar N, Spencer N, Wiklendt L, Olson T, Young W, Janssen P, et al.
Front Neurosci
. 2024 Sep;
18:1424936.
PMID: 39268036
Background: It is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced....
6.
Muir J, Iyer E, Tse Y, Sorensen J, Wu S, Eid R, et al.
Nat Neurosci
. 2024 Sep;
27(10):1966-1976.
PMID: 39237654
Learning to predict threat is essential, but equally important-yet often overlooked-is learning about the absence of threat. Here, by recording neural activity in two nucleus accumbens (NAc) glutamatergic afferents during...
7.
Gomez-Frittelli J, Devienne G, Travis L, Kyloh M, Duan X, Hibberd T, et al.
bioRxiv
. 2024 Aug;
PMID: 39149241
Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility and digestion. Neuronal subtypes in the ENS have...
8.
Hibberd T, Spencer N
Am J Physiol Gastrointest Liver Physiol
. 2024 Aug;
327(4):G483-G484.
PMID: 39136055
No abstract available.
9.
Amedzrovi Agbesi R, El Merhie A, Spencer N, Hibberd T, Chevalier N
Exp Physiol
. 2024 Jul;
109(9):1545-1556.
PMID: 38979869
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system,...
10.
Efimov A, Hibberd T, Wang Y, Wu M, Zhang K, Ting K, et al.
Biosens Bioelectron
. 2024 May;
258:116298.
PMID: 38701537
Wireless activation of the enteric nervous system (ENS) in freely moving animals with implantable optogenetic devices offers a unique and exciting opportunity to selectively control gastrointestinal (GI) transit in vivo,...