Simon Hirschberger
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Explore the profile of Simon Hirschberger including associated specialties, affiliations and a list of published articles.
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13
Citations
180
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Recent Articles
1.
Hirschberger S, Effinger D, Yoncheva P, Schmid A, Weis M, Holdt L, et al.
iScience
. 2024 Dec;
27(12):111291.
PMID: 39628567
A ketogenic diet (KD) is increasingly debated as a countermeasure against nutrition-related modern diseases. While being immunologically beneficial, KD is still suspected of having severe metabolic side effects and negatively...
2.
Rahmel T, Effinger D, Bracht T, Griep L, Koos B, Sitek B, et al.
Sci Transl Med
. 2024 Jul;
16(755):eadn9285.
PMID: 38985853
Patients with sepsis experience metabolic and immunologic dysfunction that may be amplified by standard carbohydrate-based nutrition. A ketogenic diet (KD) may offer an immunologically advantageous alternative, although clinical evidence is...
3.
Effinger D, Hirschberger S, Yoncheva P, Schmid A, Heine T, Newels P, et al.
Clin Nutr
. 2023 Jun;
42(7):1202-1212.
PMID: 37270344
Background: Western dietary habits (WD) have been shown to promote chronic inflammation, which favors the development of many of today's non-communicable diseases. Recently, ketogenic diets (KD) have emerged as an...
4.
Muller M, Stihl C, Schmid A, Hirschberger S, Mitsigiorgi R, Holzer M, et al.
Front Physiol
. 2023 May;
14:1108966.
PMID: 37123277
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of upper airway obstruction and subsequent hypoxia. In patients with OSA, severity and number of these...
5.
Hirschberger S, Schmid A, Kreth S
Anaesthesiologie
. 2023 Feb;
72(4):229-244.
PMID: 36797533
Critically ill patients often suffer from a complex and severe immunological dysfunction. The differentiation and function of human immune cells are fundamentally controlled through metabolic processes. New concepts of immunonutrition...
6.
Tomasi S, Li L, Hinske L, Tomasi R, Amini M, Strauss G, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142632
During the onset of acute inflammation, rapid trafficking of leukocytes is essential to mount appropriate immune responses towards an inflammatory insult. Monocytes are especially indispensable for counteracting the inflammatory stimulus,...
7.
Hirschberger S, Gellert L, Effinger D, Muenchhoff M, Herrmann M, Briegel J, et al.
Front Med (Lausanne)
. 2022 Jul;
9:923502.
PMID: 35783654
Severe COVID-19 is characterized by profound CD8 T-cell dysfunction, which cannot be specifically treated to date. We here investigate whether metabolic CD8 T-cell reprogramming by ketone bodies could be a...
8.
Muller M, Hubner M, Li L, Tomasi S, Liesske V, Effinger D, et al.
Front Immunol
. 2022 Apr;
13:826047.
PMID: 35401562
Opening of the endothelial barrier and targeted infiltration of leukocytes into the affected tissue are hallmarks of the inflammatory response. The molecular mechanisms regulating these processes are still widely elusive....
9.
Hirschberger S, Strauss G, Effinger D, Marstaller X, Ferstl A, Muller M, et al.
EMBO Mol Med
. 2021 Jun;
13(8):e14323.
PMID: 34151532
Very-low-carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this...
10.
Hubner M, Moellhoff N, Effinger D, Hinske C, Hirschberger S, Wu T, et al.
Neurooncol Adv
. 2020 Jul;
2(1):vdaa047.
PMID: 32642700
Background: Inflammation is an important driver of malignant glioma disease. Inflammatory mediators are not only produced by immune cells in the tumor microenvironment, but also by glioblastoma (GBM) cells themselves...