Simon Grassmann
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Explore the profile of Simon Grassmann including associated specialties, affiliations and a list of published articles.
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32
Citations
823
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Recent Articles
1.
Wethington D, Ahmad S, Potempa M, Giuliani G, Aguilar O, Poudel M, et al.
bioRxiv
. 2025 Mar;
PMID: 40060511
Natural killer (NK) cells are classically defined as innate immune cells, but experiments show that mouse cytomegalovirus (MCMV) infection in C57BL/6 mice can cause NK cells to undergo antigen-specific proliferation...
2.
Mujal A, Owyong M, Santosa E, Sauter J, Grassmann S, Pedde A, et al.
Immunity
. 2025 Mar;
58(3):585-600.e6.
PMID: 40023159
Natural killer (NK) cells possess both innate and adaptive features. Here, we investigated NK cell activation across tissues during cytomegalovirus infection, which generates antigen-specific clonal expansion and long-lived memory responses....
3.
Lemarquis A, Kousa A, Argyropoulos K, Jahn L, Gipson B, Pierce J, et al.
Immunity
. 2025 Feb;
58(2):397-411.e6.
PMID: 39892391
Thymic injury associated with disease or cancer treatment reduces T cell production and makes patients more vulnerable to infections and cancers. Here, we examined the role of regulatory T (Treg)...
4.
Kim Y, Manara F, Grassmann S, Belcheva K, Reyes K, Kim H, et al.
Cell Rep
. 2025 Jan;
44(1):115190.
PMID: 39792552
The T-cell-derived cytokine IL-21 is crucial for germinal center (GC) responses, but its precise role in B cell function has remained elusive. Using IL-21 receptor (Il21r) conditional knockout mice and...
5.
Grassmann S
J Clin Invest
. 2025 Jan;
135(1).
PMID: 39744950
Approximately 1 in 200 newborns worldwide are affected by congenital cytomegalovirus (CMV). Most of these cases are asymptomatic due to successful control of the infection by the newborn's immune system....
6.
Panjwani M, Grassmann S, Sottile R, Le Luduec J, Kontopoulos T, van der Ploeg K, et al.
Front Immunol
. 2025 Jan;
15:1499492.
PMID: 39742279
Development of antigen-specific memory upon pathogen exposure is a hallmark of the adaptive immune system. While natural killer (NK) cells are considered part of the innate immune system, humans exposed...
7.
Pedde A, Kim H, Donakonda S, Baumann T, Bayerl F, Meiser P, et al.
Cell Rep
. 2024 Nov;
43(11):114855.
PMID: 39541209
Natural killer (NK) cells are critical for anti-metastatic immunity and can eliminate metastasizing tumor cells within circulation and sites of metastatic seeding. Here, we show that disseminated tumor cells (DTCs)...
8.
Kim Y, Manara F, Grassmann S, Belcheva K, Reyes K, Kim H, et al.
bioRxiv
. 2024 Jul;
PMID: 39026745
The cytokine interleukin-21 (IL-21) is a pivotal T cell-derived signal crucial for germinal center (GC) responses, but the precise mechanisms by which IL-21 influences B cell function remain elusive. Here,...
9.
Ding Y, Lavaert M, Grassmann S, Band V, Chi L, Das A, et al.
Nat Immunol
. 2024 Jul;
25(8):1507.
PMID: 38987653
No abstract available.
10.
Ding Y, Lavaert M, Grassmann S, Band V, Chi L, Das A, et al.
Nat Immunol
. 2024 Jun;
25(7):1183-1192.
PMID: 38872000
Natural killer (NK) cells function by eliminating virus-infected or tumor cells. Here we identified an NK-lineage-biased progenitor population, referred to as early NK progenitors (ENKPs), which developed into NK cells...