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Simon G Williams

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Articles 109
Citations 2076
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Recent Articles
11.
Bradley J, Schelbert E, Bonnett L, Lewis G, Lagan J, Orsborne C, et al.
Heart . 2023 Aug; 110(3):195-201. PMID: 37567614
Objective: Identification of patients at risk of adverse outcome from heart failure (HF) at an early stage is a priority. Growth differentiation factor (GDF)-15 has emerged as a potentially useful...
12.
Soltani F, Lewis G, Rosala-Hallas A, Dodd S, Schelbert E, Williams S, et al.
J Card Fail . 2023 Mar; 29(7):1091-1096. PMID: 36921885
Objectives: Medication adherence in patients with heart failure with preserved ejection fraction is unclear. This study sought to evaluate treatment adherence in the Pirfenidone in Patients with Heart Failure and...
13.
Byrne D, Williams S, Nakev A, Frain S, Baross S, Vestbo J, et al.
Sci Rep . 2022 Nov; 12(1):18703. PMID: 36333391
Adults with congenital heart disease (CHD) face increased risk of various comorbid diseases. Previous work on lung dysfunction in this population has mainly focused on restrictive lung disease, in patients...
14.
Lewis G, Rosala-Hallas A, Dodd S, Schelbert E, Williams S, Cunnington C, et al.
J Am Heart Assoc . 2022 Jul; 11(14):e024668. PMID: 35861823
Background Growth differentiation factor 15 (GDF-15) is elevated in heart failure with preserved ejection fraction and is associated with adverse outcome, but its relationship with myocardial fibrosis and other characteristics...
15.
Lewis G, Rosala-Hallas A, Dodd S, Schelbert E, Williams S, Cunnington C, et al.
J Cardiovasc Transl Res . 2022 Jul; 15(6):1436-1443. PMID: 35790651
Myocardial fibrosis, measured using cardiovascular magnetic resonance extracellular volume (ECV), is associated with adverse outcome in heart failure with preserved ejection fraction, but the mechanisms by which myocardial fibrosis exerts...
16.
Chelu A, Williams S, Keavney B, Talavera D
J Hum Genet . 2022 Jun; 67(10):613-615. PMID: 35718831
Although several genes involved in the development of Tetralogy of Fallot have been identified, no genetic diagnosis is available for the majority of patients. Low statistical power may have prevented...
17.
Bradley J, Schelbert E, Bonnett L, Lewis G, Lagan J, Orsborne C, et al.
Lancet Digit Health . 2022 May; 4(6):e445-e454. PMID: 35562273
Background: Identifying people who are at risk of being admitted to hospital (hospitalised) for heart failure and death, and particularly those who have not previously been hospitalised for heart failure,...
18.
Lewis G, Rosala-Hallas A, Dodd S, Schelbert E, Williams S, Cunnington C, et al.
Int J Cardiovasc Imaging . 2022 Feb; 38(7):1569-1578. PMID: 35138474
Myocardial fibrosis, measured using magnetic resonance extracellular volume (ECV), associates with adverse outcome in heart failure with preserved ejection fraction (HFpEF). In the PIROUETTE (The Pirfenidone in Patients with Heart...
19.
Liu Y, Williams S, Jones H, Keavney B, Choy M
Sci Rep . 2021 Dec; 11(1):23233. PMID: 34853328
The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process....
20.
Hochberg I, Demain L, Richer J, Thompson K, Urquhart J, Rea A, et al.
Am J Hum Genet . 2021 Oct; 108(11):2195-2204. PMID: 34715011
Human mitochondrial RNase P (mt-RNase P) is responsible for 5' end processing of mitochondrial precursor tRNAs, a vital step in mitochondrial RNA maturation, and is comprised of three protein subunits:...