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Simon Christ

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Articles 16
Citations 453
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Recent Articles
1.
Fischer A, Han W, Hu S, Muck-Hausl M, Wannemacher J, Kadri S, et al.
Nat Commun . 2025 Feb; 16(1):1911. PMID: 39994215
No abstract available.
2.
Fischer A, Han W, Hu S, Hausl M, Muck-Hausl M, Wannemacher J, et al.
Nat Commun . 2025 Jan; 16(1):173. PMID: 39747171
Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung fibrosis and observe disassembly and transfer of connective tissue...
3.
Stemwedel K, Haase N, Christ S, Bogdanova N, Rudorf S
NAR Genom Bioinform . 2024 Aug; 6(3):lqae110. PMID: 39184377
Ionizing radiation (IR) in high doses is generally lethal to most organisms. Investigating mechanisms of radiation resistance is crucial for gaining insights into the underlying cellular responses and understanding the...
4.
Haase N, Holtkamp W, Christ S, Heinemann D, Rodnina M, Rudorf S
PLoS Comput Biol . 2024 Mar; 20(3):e1011918. PMID: 38442108
Processive enzymes like polymerases or ribosomes are often studied in bulk experiments by monitoring time-dependent signals, such as fluorescence time traces. However, due to biomolecular process stochasticity, ensemble signals may...
5.
Fischer A, Correa-Gallegos D, Wannemacher J, Christ S, Machens H, Rinkevich Y
Nat Protoc . 2023 Aug; 18(10):2876-2890. PMID: 37558896
Connective tissues are essential building blocks for organ development, repair and regeneration. However, we are at the early stages of understanding connective tissue dynamics. Here, we detail a method that...
6.
Kalgudde Gopal S, Dai R, Stefanska A, Ansari M, Zhao J, Ramesh P, et al.
Nat Commun . 2023 May; 14(1):3020. PMID: 37230982
The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes...
7.
Fischer A, Wannemacher J, Christ S, Koopmans T, Kadri S, Zhao J, et al.
Nat Immunol . 2022 Mar; 23(4):518-531. PMID: 35354953
Internal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix around the mesothelium lining in mouse peritoneum,...
8.
Jiang D, Christ S, Correa-Gallegos D, Ramesh P, Kalgudde Gopal S, Wannemacher J, et al.
Nat Commun . 2020 Nov; 11(1):5653. PMID: 33159076
Scars are more severe when the subcutaneous fascia beneath the dermis is injured upon surgical or traumatic wounding. Here, we present a detailed analysis of fascia cell mobilisation by using...
9.
Christ S, Litschel T, Schwille P, Lipowsky R
Soft Matter . 2020 Sep; 17(2):319-330. PMID: 32914814
Reaction-diffusion systems encapsulated within giant unilamellar vesicles (GUVs) can lead to shape oscillations of these vesicles as recently observed for the bacterial Min protein system. This system contains two Min...
10.
Fischer A, Koopmans T, Ramesh P, Christ S, Strunz M, Wannemacher J, et al.
Nat Commun . 2020 Jun; 11(1):3068. PMID: 32555155
Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions are a major cause of post-operative and dialysis-related complications, yet their patho-mechanism remains elusive, and prevention agents...