Simina Grigoriu
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Explore the profile of Simina Grigoriu including associated specialties, affiliations and a list of published articles.
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10
Citations
584
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Recent Articles
1.
Lee Y, Sickmier E, Grigoriu S, Castro J, Boriack-Sjodin P
Acta Crystallogr D Struct Biol
. 2023 Oct;
79(Pt 11):980-991.
PMID: 37860960
DHX9 is a DExH-box RNA helicase with versatile functions in transcription, translation, RNA processing and regulation of DNA replication. DHX9 has recently emerged as a promising target for oncology, but...
2.
Li Y, Sheftic S, Grigoriu S, Schwieters C, Page R, Peti W
Sci Adv
. 2020 Sep;
6(27).
PMID: 32936779
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the Ser/Thr phosphatase calcineurin (CN). It has been shown that excessive inhibition of CN is a critical factor for Down...
3.
Nasr M, Baptista D, Strauss M, Sun Z, Grigoriu S, Huser S, et al.
Nat Methods
. 2016 Nov;
14(1):49-52.
PMID: 27869813
We engineered covalently circularized nanodiscs (cNDs) which, compared with standard nanodiscs, exhibit enhanced stability, defined diameter sizes and tunable shapes. Reconstitution into cNDs enhanced the quality of nuclear magnetic resonance...
4.
Goricanec D, Stehle R, Egloff P, Grigoriu S, Pluckthun A, Wagner G, et al.
Proc Natl Acad Sci U S A
. 2016 Jun;
113(26):E3629-38.
PMID: 27298341
Heterotrimeric G proteins play a pivotal role in the signal-transduction pathways initiated by G-protein-coupled receptor (GPCR) activation. Agonist-receptor binding causes GDP-to-GTP exchange and dissociation of the Gα subunit from the...
5.
Grigoriu S, Bond R, Cossio P, Chen J, Ly N, Hummer G, et al.
PLoS Biol
. 2013 Mar;
11(2):e1001492.
PMID: 23468591
Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the...
6.
Brown B, Lord D, Grigoriu S, Peti W, Page R
J Biol Chem
. 2012 Nov;
288(2):1286-94.
PMID: 23172222
Bacterial biofilms are complex communities of cells containing an increased prevalence of dormant cells known as persisters, which are characterized by an up-regulation of genes known as toxin-antitoxin (TA) modules....
7.
Eibl C, Grigoriu S, Hessenberger M, Wenger J, Puehringer S, Pinheiro A, et al.
Biochemistry
. 2012 Aug;
51(37):7330-41.
PMID: 22928810
NLRP4 is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family of cytosolic receptors and a member of an inflammation signaling cascade. Here, we present the crystal structure...
8.
Kim Y, Wang X, Zhang X, Grigoriu S, Page R, Peti W, et al.
Environ Microbiol
. 2010 Jan;
12(5):1105-21.
PMID: 20105222
Previously we identified that the Escherichia coli protein MqsR (YgiU) functions as a toxin and that it is involved in the regulation of motility by quorum sensing signal autoinducer-2 (AI-2)....
9.
Brown B, Grigoriu S, Kim Y, Arruda J, Davenport A, Wood T, et al.
PLoS Pathog
. 2009 Dec;
5(12):e1000706.
PMID: 20041169
One mechanism by which bacteria survive environmental stress is through the formation of bacterial persisters, a sub-population of genetically identical quiescent cells that exhibit multidrug tolerance and are highly enriched...
10.
Zaidi S, Pande S, Pratap J, Gaur T, Grigoriu S, Ali S, et al.
Proc Natl Acad Sci U S A
. 2007 Dec;
104(50):19861-6.
PMID: 18077419
The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated in metastatic breast and prostate cancer cells. Thus, Runx2 may...