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Simar Pal Singh

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Articles 10
Citations 429
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Recent Articles
1.
Dunlock V, Arp A, Singh S, Charrin S, Nguyen V, Jansen E, et al.
Cell Rep . 2022 Jun; 39(13):111006. PMID: 35767951
T cells depend on the phosphatase CD45 to initiate T cell receptor signaling. Although the critical role of CD45 in T cells is established, the mechanisms controlling function and localization...
2.
Rip J, de Bruijn M, Neys S, Singh S, Willar J, van Hulst J, et al.
Eur J Immunol . 2021 Jul; 51(9):2251-2265. PMID: 34323286
Bruton's tyrosine kinase (Btk) is a crucial signaling molecule in BCR signaling and a key regulator of B- cell differentiation and function. Btk inhibition has shown impressive clinical efficacy in...
3.
Dhoot S, Mittal S, Singh S, Patel V, Kasliwal R, Mehta V
Future Sci OA . 2020 Jun; 6(5):FSO467. PMID: 32518682
There is a very high prevalence of iron deficiency anemia in patients with systolic heart failure. The present study is a prospective, parallel, 1:1 randomized controlled trial of intravenous ferric-carboxy...
4.
Singh S, de Bruijn M, Velaso Gago da Graca C, Corneth O, Rip J, Stadhouders R, et al.
J Immunol . 2019 Dec; 204(2):360-374. PMID: 31836657
Balanced activity of kinases and phosphatases downstream of the BCR is essential for B cell differentiation and function and is disturbed in chronic lymphocytic leukemia (CLL). In this study, we...
5.
Singh S, Dammeijer F, Hendriks R
Mol Cancer . 2019 Apr; 18(1):79. PMID: 30943993
Following publication of the original article [1], the authors reported an error in Table 1.
6.
Rip J, de Bruijn M, Appelman M, Singh S, Hendriks R, Corneth O
Front Immunol . 2019 Feb; 10:95. PMID: 30761150
Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that...
7.
Singh S, de Bruijn M, de Almeida M, Meijers R, Nitschke L, Langerak A, et al.
Front Immunol . 2018 Oct; 9:1996. PMID: 30271400
Chronic lymphocytic leukemia (CLL) can be divided into prognostically distinct subsets with stereotyped or non-stereotyped, mutated or unmutated B cell receptors (BCRs). Individual subsets vary in antigen specificity and origin,...
8.
Singh S, Dammeijer F, Hendriks R
Mol Cancer . 2018 Feb; 17(1):57. PMID: 29455639
Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell...
9.
Singh S, Pillai S, de Bruijn M, Stadhouders R, Corneth O, van den Ham H, et al.
Oncotarget . 2017 Oct; 8(42):71981-71995. PMID: 29069762
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature CD5 B cells in blood. Spontaneous apoptosis of CLL cells has hampered in-depth investigation of CLL pathogenesis. Here we...
10.
Pedroza-Gonzalez A, Zhou G, Singh S, Boor P, Pan Q, Grunhagen D, et al.
Oncoimmunology . 2015 Nov; 4(12):e1051297. PMID: 26587321
In liver cancer tumor-infiltrating regulatory T cells (Ti-Treg) are potent suppressors of tumor-specific T-cell responses and express high levels of the Treg-associated molecules cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and...