Silvia Sgambellone
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Explore the profile of Silvia Sgambellone including associated specialties, affiliations and a list of published articles.
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24
Citations
120
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Recent Articles
1.
Tosh D, Pavan M, Clark A, Lammers J, Villano S, Marri S, et al.
J Med Chem
. 2024 Nov;
67(23):21264-21291.
PMID: 39589936
Rigidified nucleoside derivatives with (N)-methanocarba replacement of ribose have been repurposed as peripheral subtype-selective 5-HT serotonin receptor antagonists for heart and lung fibrosis and intestinal/vascular conditions. 4'-Cyano derivative (MRS8209; ,...
2.
Sgambellone S, Khanfar M, Marri S, Villano S, Nardini P, Frank A, et al.
Biomed Pharmacother
. 2024 Sep;
180:117454.
PMID: 39321511
Glaucoma is a degenerative optic neuropathy in which the degeneration of optic nerve and blindness occur. The main cause is a malfunction of ciliary processes (protrusions of the ciliary bodies)...
3.
Kilbile J, Sapkal S, Renzi G, DAgostino I, Boudjelal M, Tamboli Y, et al.
ChemMedChem
. 2024 Sep;
19(24):e202400601.
PMID: 39319579
A series of 2,4-dichloro-5-{[4-(phenylsulfonyl)piperazin-1-yl]carbonyl}benzenesulfonamides were designed and synthesized through amidation of Lasamide 1 with substituted piperazines. The newly obtained compounds demonstrated remarkable inhibition potency and selectivity for the human (h)...
4.
Shi S, Zheng Y, Goulding J, Marri S, Lucarini L, Konecny B, et al.
Biochem Pharmacol
. 2024 Jun;
226:116396.
PMID: 38942089
This study introduces (S)-Opto-prop-2, a second-generation photoswitchable ligand designed for precise modulation of β-adrenoceptor (βAR). Synthesised by incorporating an azobenzene moiety with propranolol, (S)-Opto-prop-2 exhibited a high PSS (photostationary state...
5.
Angeli A, Chelli I, Lucarini L, Sgambellone S, Marri S, Villano S, et al.
J Med Chem
. 2024 Jan;
67(4):3066-3089.
PMID: 38266245
Glaucoma, a leading cause of irreversible vision loss worldwide, is characterized by elevated intraocular pressure (IOP), a well-established risk factor across all its forms. We present the design and synthesis...
6.
Sgambellone S, Febo M, Durante M, Marri S, Villano S, Bereshchenko O, et al.
Inflamm Res
. 2023 Oct;
72(10-11):2037-2052.
PMID: 37815550
Introduction: This study investigates the interactions between histaminergic system and glucocorticoid-induced leucin zipper (GILZ) in the inflammatory process and glucocorticoid modulation in lung fibrosis. Methods: Wild-type (WT) and GILZ Knock-Out...
7.
Sgambellone S, Marri S, Villano S, Masini E, Provensi G, Bastia E, et al.
Transl Vis Sci Technol
. 2023 Sep;
12(9):22.
PMID: 37750744
Purpose: The purpose of this study was to assess the retinal protective activity and ocular hemodynamics after NCX 470 (0.1%) compared to bimatoprost administered as the US Food and Drug...
8.
Sgambellone S, Marri S, Catarinicchia S, Pini A, Tosh D, Jacobson K, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362112
Adenosine receptors (ARs) are involved in the suppression and development of inflammatory and fibrotic conditions. Specifically, AR activation promotes differentiation of lung fibroblasts into myofibroblasts, typical of a fibrotic event....
9.
Bastia E, Sgambellone S, Lucarini L, Provensi G, Brambilla S, Galli C, et al.
J Ocul Pharmacol Ther
. 2022 Jul;
38(7):496-504.
PMID: 35787180
Determine whether NCX 470, a nitric oxide (NO)-donating bimatoprost with clinically demonstrated intraocular pressure (IOP)-lowering effects, improves ocular hemodynamics and retinal physiology. Endothelin-1 (ET-1)-induced ischemia/reperfusion model in New Zealand white...
10.
Sgambellone S, Marri S, Masini E, Lucarini L
Biomolecules
. 2022 May;
12(5).
PMID: 35625537
The first properties of histamine (HA) that were elucidated were vasodilation and contraction of smooth muscles in the gut after stimulating gastric acid secretion and constriction of the bronchial area...