Silvia Fademrecht
Overview
Explore the profile of Silvia Fademrecht including associated specialties, affiliations and a list of published articles.
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7
Citations
86
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Recent Articles
1.
Demming R, Hammer S, Nestl B, Gergel S, Fademrecht S, Pleiss J, et al.
Angew Chem Int Ed Engl
. 2018 Sep;
58(1):173-177.
PMID: 30256501
The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long-standing challenge in catalysis. Here we report that an engineered fatty...
2.
Lenz M, Fademrecht S, Sharma M, Pleiss J, Grogan G, Nestl B
Protein Eng Des Sel
. 2018 May;
31(4):109-120.
PMID: 29733377
We report the exploration of the evolutionary relationship between imine reductases (IREDs) and other dehydrogenases. This approach is informed by the sequence similarity between these enzyme families and the recently...
3.
Buchholz P, Fademrecht S, Pleiss J
PLoS One
. 2017 Dec;
12(12):e0189646.
PMID: 29261740
The currently known protein sequences are not distributed equally in sequence space, but cluster into families. Analyzing the cluster size distribution gives a glimpse of the large and unknown extant...
4.
Krone M, Friess F, Scharnowski K, Reina G, Fademrecht S, Kulschewski T, et al.
IEEE Trans Vis Comput Graph
. 2016 Nov;
23(1):701-710.
PMID: 27875185
We present Molecular Surface Maps, a novel, view-independent, and concise representation for molecular surfaces. It transfers the well-known world map metaphor to molecular visualization. Our application maps the complex molecular...
5.
Zeil C, Widmann M, Fademrecht S, Vogel C, Pleiss J
Antimicrob Agents Chemother
. 2016 Feb;
60(5):2709-17.
PMID: 26883706
The Lactamase Engineering Database (www.LacED.uni-stuttgart.de) was developed to facilitate the classification and analysis of TEM β-lactamases. The current version contains 474 TEM variants. Two hundred fifty-nine variants form a large...
6.
Fademrecht S, Scheller P, Nestl B, Hauer B, Pleiss J
Proteins
. 2016 Feb;
84(5):600-10.
PMID: 26857686
Chiral amines are valuable building blocks for the production of a variety of pharmaceuticals, agrochemicals and other specialty chemicals. Only recently, imine reductases (IREDs) were discovered which catalyze the stereoselective...
7.
Scheller P, Fademrecht S, Hofelzer S, Pleiss J, Leipold F, Turner N, et al.
Chembiochem
. 2014 Aug;
15(15):2201-4.
PMID: 25163890
Reducing reactions are among the most useful transformations for the generation of chiral compounds in the fine-chemical industry. Because of their exquisite selectivities, enzymatic approaches have emerged as the method...