Sihyun Ham
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Explore the profile of Sihyun Ham including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Cho M, Chong S, Ham S, Shin S
J Comput Chem
. 2023 Jun;
44(25):1976-1985.
PMID: 37352129
Understanding the molecular basis for protein stability requires a thermodynamic analysis of protein folding. Thermodynamic analysis is often performed by sampling many atomistic conformations using molecular simulations that employ either...
2.
Chong S, Ham S
J Comput Chem
. 2022 Dec;
44(9):1002-1009.
PMID: 36571461
The question of whether amino acids critical to protein folding kinetics are evolutionarily conserved has been investigated intensively in the past, but no consensus has yet been reached. Recently, we...
3.
Lee J, Seok C, Ham S, Chong S
Proteins
. 2022 Dec;
91(5):694-704.
PMID: 36564921
Understanding how protein-protein binding affinity is determined from molecular interactions at the interface is essential in developing protein therapeutics such as antibodies, but this has not yet been fully achieved....
4.
Chong S, Ham S
Chem Sci
. 2022 Mar;
12(16):5944-5951.
PMID: 35342544
Cooperativity is considered to be a key organizing principle behind biomolecular assembly, recognition and folding. However, it has remained very challenging to quantitatively characterize how cooperative processes occur on a...
5.
Kim D, Chong S, Shin S, Ham S
Biochim Biophys Acta Proteins Proteom
. 2021 Dec;
1870(3):140746.
PMID: 34942360
Mutations in the fasciclin 1 domain 4 (FAS1-4) of transforming growth factor β-induced protein (TGFBIp) are associated with insoluble extracellular deposits and corneal dystrophies (CDs). The decrease in solubility upon...
6.
Cho M, Chong S, Shin S, Ham S
J Phys Chem B
. 2021 Jun;
125(26):7108-7116.
PMID: 34165991
The native structure of a protein is stabilized by a number of interactions such as main-chain hydrogen bonds and side-chain hydrophobic contacts. However, it has been challenging to determine how...
7.
Lee J, Chong S, Ham S
Sci Rep
. 2020 Dec;
10(1):21191.
PMID: 33273506
Protein aggregation is a major concern in biotherapeutic applications of monoclonal antibodies. Introducing charged mutations is among the promising strategies to improve aggregation resistance. However, the impact of such mutations...
8.
Im H, Ham S
PLoS One
. 2020 May;
15(4):e0232613.
PMID: 32353067
Inactivation of the tumor suppressor p53 resulting from the binding with a negative regulator HDM2 is among the predominant defects in human cancers. p53-mimicking peptides whose conformational and proteolytic stability...
9.
Lee Y, Im H, Das S, Oh M, Lee J, Ham S, et al.
Chem Commun (Camb)
. 2019 Oct;
55(88):13311-13314.
PMID: 31631199
Herein, we report a strategy for generating conformationally restricted α-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of α-helix mimetics. We demonstrate that...
10.
Chong S, Ham S
Sci Rep
. 2019 Oct;
9(1):14927.
PMID: 31624293
Folding funnel is the essential concept of the free energy landscape for ordered proteins. How does this concept apply to intrinsically disordered proteins (IDPs)? Here, we address this fundamental question...