Sigrid A Langhans
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Explore the profile of Sigrid A Langhans including associated specialties, affiliations and a list of published articles.
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30
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1260
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Recent Articles
1.
Ajongbolo A, Langhans S
Front Cell Dev Biol
. 2025 Feb;
13:1522705.
PMID: 39936032
YAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. Both are known to play a...
2.
Stauff E, Xu W, Kecskemethy H, Langhans S, Kandula V, Averill L, et al.
Biomolecules
. 2025 Jan;
15(1).
PMID: 39858441
Tryptophan (Trp)-based radiotracers have excellent potential for imaging many different types of brain pathology because of their involvement with both the serotonergic and kynurenine (KYN) pathways. However, radiotracers specific to...
3.
Xu W, Langhans S, Johnson D, Stauff E, Kandula V, Kecskemethy H, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273366
Angiotensin-converting enzymes (ACE) are well-known for their roles in both blood pressure regulation via the renin-angiotensin system as well as functions in fertility, immunity, hematopoiesis, and many others. The two...
4.
Yue X, Stauff E, Boyapati S, Langhans S, Xu W, Makrogiannis S, et al.
Pharmaceuticals (Basel)
. 2024 Jun;
17(6).
PMID: 38931352
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral...
5.
Nikam R, Kecskemethy H, Kandula V, Averill L, Langhans S, Yue X
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901893
Abusive head trauma (AHT) is a serious traumatic brain injury and the leading cause of death in children younger than 2 years. The development of experimental animal models to simulate...
6.
Sperle K, Pochan D, Langhans S
Methods Mol Biol
. 2022 Dec;
2614:369-381.
PMID: 36587136
Our increased understanding of how a cell's microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures for drug discovery. Particularly, scaffold-based 3D cultures are expected to...
7.
Nikam R, Yue X, Kaur G, Kandula V, Khair A, Kecskemethy H, et al.
Cancers (Basel)
. 2022 Jul;
14(14).
PMID: 35884462
Central nervous system tumors are the most common pediatric solid tumors; they are also the most lethal. Unlike adults, childhood brain tumors are mostly primary in origin and differ in...
8.
Yue X, Nikam R, Kecskemethy H, Kandula V, Falchek S, Averill L, et al.
J Vis Exp
. 2021 Oct;
(175).
PMID: 34633385
The kynurenine pathway (KP) is a primary route for tryptophan metabolism. Evidence strongly suggests that metabolites of the KP play a vital role in tumor proliferation, epilepsy, neurodegenerative diseases, and...
9.
Nikam R, Yue X, Kandula V, Paudyal B, Langhans S, Averill L, et al.
Pediatr Radiol
. 2021 May;
51(6):966-970.
PMID: 33999238
Abusive head trauma (AHT) is a leading cause of mortality and morbidity in child abuse, with a mortality rate of approximately 25%. In survivors, the prognosis remains dismal, with high...
10.
Li Z, Langhans S
Front Oncol
. 2021 Apr;
11:620831.
PMID: 33869004
After leukemia, tumors of the brain and spine are the second most common form of cancer in children. Despite advances in treatment, brain tumors remain a leading cause of death...