Sigfrido Scarpa
Overview
Explore the profile of Sigfrido Scarpa including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
932
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Recent Articles
1.
Monti N, Cavallaro R, Stoccoro A, Nicolia V, Scarpa S, Kovacs G, et al.
Epigenetics
. 2020 Feb;
15(8):781-799.
PMID: 32019393
The Presenilin1 () gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in...
2.
Delfino D, Rossetti D, Martelli C, Inserra I, Vincenzoni F, Castagnola M, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2019 Jun;
1124:165-172.
PMID: 31202182
The multifactorial nature of Late Onset Alzheimer's Disease (LOAD), the AD form of major relevance on epidemiological and social aspects, has driven the original investigation by LC-MS and top-down proteomics...
3.
Cavallaro R, Nicolia V, Fiorenza M, Scarpa S, Fuso A
Antioxidants (Basel)
. 2017 Oct;
6(4).
PMID: 28973985
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated...
4.
Nicolia V, Ciraci V, Cavallaro R, Ferrer I, Scarpa S, Fuso A
Curr Alzheimer Res
. 2017 Feb;
14(7):753-759.
PMID: 28176663
Background: The GSK3β has been associated to pathological functions in neurodegenerative diseases. This kinase is involved in hyperphosphorylation of microtubule-associated tau protein, leading to aggregation andformation of NFTs. It has...
5.
Nicolia V, Cavallaro R, Lopez-Gonzalez I, Maccarrone M, Scarpa S, Ferrer I, et al.
J Neuropathol Exp Neurol
. 2017 Jan;
76(1):27-31.
PMID: 28053004
By means of functional genomics analysis, we recently described the mRNA expression profiles of various genes involved in the neuroinflammatory response in the brains of subjects with late-onset Alzheimer Disease...
6.
Palladino G, Nicolia V, Kovacs G, Canterini S, Ciraci V, Fuso A, et al.
J Mol Neurosci
. 2016 Nov;
61(3):359-367.
PMID: 27866325
Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a...
7.
Martire S, Fuso A, Mosca L, Forte E, Correani V, Fontana M, et al.
J Alzheimers Dis
. 2016 Aug;
54(1):307-24.
PMID: 27567805
Amyloid-beta peptide accumulation in the brain is one of the main hallmarks of Alzheimer's disease. The amyloid aggregation process is associated with the generation of free radical species responsible for...
8.
Fuso A, Ferraguti G, Scarpa S, Ferrer I, Lucarelli M
PLoS One
. 2015 Feb;
10(2):e0118318.
PMID: 25692551
Discordant results obtained in bisulfite assays using MethPrimers (PCR primers designed using MethPrimer software or assuming that non-CpGs cytosines are non methylated) versus primers insensitive to cytosine methylation lead us...
9.
Persichilli S, Gervasoni J, Di Napoli A, Fuso A, Nicolia V, Giardina B, et al.
J Alzheimers Dis
. 2015 Feb;
44(4):1323-31.
PMID: 25672765
Widely confirmed reports were published on association between hyperhomocysteinemia, B vitamin deficiency, oxidative stress, and amyloid-β in Alzheimer's disease (AD). Homocysteine, cysteine, cysteinylglycine and glutathione are metabolically interrelated thiols that...
10.
Martire S, Fuso A, Rotili D, Tempera I, Giordano C, De Zottis I, et al.
PLoS One
. 2013 Oct;
8(9):e72169.
PMID: 24086258
Amyloid beta peptide (Aβ) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent activation of poly (ADP-ribose) polymerase (PARP-1). To elucidate...