Siewert Hugelier
Overview
Explore the profile of Siewert Hugelier including associated specialties, affiliations and a list of published articles.
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27
Citations
100
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Recent Articles
1.
Harke J, Lee J, Nguyen S, Arab A, Rakowiecki S, Hugelier S, et al.
Mol Cell
. 2024 Nov;
84(24):4698-4710.e6.
PMID: 39579767
Developmental gene regulation requires input from enhancers spread over large genomic distances. Our understanding of long-range enhancer-promoter (E-P) communication, characterized as loops, remains incomplete without addressing the role of intervening...
2.
Fenton A, Peng R, Bond C, Hugelier S, Lakadamyali M, Chang Y, et al.
Nat Cell Biol
. 2024 Nov;
26(12):2061-2074.
PMID: 39548330
Fragile X messenger ribonucleoprotein (FMRP) is a critical regulator of translation, whose dysfunction causes fragile X syndrome. FMRP dysfunction disrupts mitochondrial health in neurons, but it is unclear how FMRP...
3.
Bond C, Hugelier S, Xing J, Sorokina E, Lakadamyali M
J Cell Biol
. 2024 Nov;
224(1).
PMID: 39485275
Late endosomes/lysosomes (LELs) are crucial for numerous physiological processes and their dysfunction is linked to many diseases. Proteomic analyses have identified hundreds of LEL proteins; however, whether these proteins are...
4.
Hugelier S, Tang Q, Kim H, Gyparaki M, Bond C, Santiago-Ruiz A, et al.
Nat Methods
. 2024 Sep;
21(10):1909-1915.
PMID: 39256629
Single-molecule localization microscopy (SMLM) has gained widespread use for visualizing the morphology of subcellular organelles and structures with nanoscale spatial resolution. However, analysis tools for automatically quantifying and classifying SMLM...
5.
Van den Eynde R, Hertel F, Abakumov S, Krajnik B, Hugelier S, Auer A, et al.
Nat Methods
. 2024 Sep;
21(10):1801-1805.
PMID: 39242832
We present a way to encode more information in fluorescence imaging by splitting the original point spread function (PSF), which offers broadband operation and compatibility with other PSF engineering modalities...
6.
Santiago-Ruiz A, Hugelier S, Bond C, Lee E, Lakadamyali M
bioRxiv
. 2024 May;
PMID: 38712162
Tau aggregation plays a critical role in Alzheimer's Disease (AD), where tau neurofibrillary tangles (NFTs) are a key pathological hallmark. While much attention has been given to NFTs, emerging evidence...
7.
Bond C, Hugelier S, Xing J, Sorokina E, Lakadamyali M
bioRxiv
. 2024 Apr;
PMID: 38562776
Summary: This study develops a multiplexed and quantitative DNA-PAINT super-resolution imaging pipeline to investigate the distribution of late endosomal/lysosomal (LEL) proteins across individual LELs, revealing cell-type specific LEL sub-populations with...
8.
Tang Q, Sensale S, Bond C, Xing J, Qiao A, Hugelier S, et al.
Curr Biol
. 2023 Nov;
33(23):5169-5184.e8.
PMID: 37979580
Microtubules in cells consist of functionally diverse subpopulations carrying distinct post-translational modifications (PTMs). Akin to the histone code, the tubulin code regulates a myriad of microtubule functions, ranging from intracellular...
9.
Hugelier S, Kim H, Gyparaki M, Bond C, Tang Q, Santiago-Ruiz A, et al.
bioRxiv
. 2023 May;
PMID: 37215010
We introduce a new automated machine learning analysis pipeline to precisely classify cellular structures captured through single molecule localization microscopy, which we call ECLiPSE (Enhanced Classification of Localized Pointclouds by...
10.
Hugelier S, Colosi P, Lakadamyali M
Annu Rev Biophys
. 2023 May;
52:139-160.
PMID: 37159293
Super-resolution fluorescence microscopy allows the investigation of cellular structures at nanoscale resolution using light. Current developments in super-resolution microscopy have focused on reliable quantification of the underlying biological data. In...