Sidney Chan
Overview
Explore the profile of Sidney Chan including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
41
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Recent Articles
1.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, et al.
Nature
. 2024 Sep;
638(8051):796-804.
PMID: 39322662
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras (LYTACs) and cytokine receptor-targeting chimeras (KineTACs) have used this to...
2.
Huang B, Coventry B, Borowska M, Arhontoulis D, Exposit M, Abedi M, et al.
Nat Commun
. 2024 Aug;
15(1):7064.
PMID: 39152100
Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory...
3.
Hendricks G, Grigoryan L, Navarro M, Catanzaro N, Hubbard M, Powers J, et al.
bioRxiv
. 2024 Aug;
PMID: 39091730
Both protein nanoparticle and mRNA vaccines were clinically de-risked during the COVID-19 pandemic. These vaccine modalities have complementary strengths: antigen display on protein nanoparticles can enhance the magnitude, quality, and...
4.
Yang E, Divine R, Miranda M, Borst A, Sheffler W, Zhang J, et al.
Nat Struct Mol Biol
. 2024 May;
31(9):1404-1412.
PMID: 38724718
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design...
5.
Bennett N, Watson J, Ragotte R, Borst A, See D, Weidle C, et al.
bioRxiv
. 2024 Apr;
PMID: 38562682
Despite the central role that antibodies play in modern medicine, there is currently no way to rationally design novel antibodies to bind a specific epitope on a target. Instead, antibody...
6.
Ellis D, Dosey A, Boyoglu-Barnum S, Park Y, Gillespie R, Syeda H, et al.
Cell Rep
. 2023 Dec;
42(12):113552.
PMID: 38096058
Immunogen design approaches aim to control the specificity and quality of antibody responses elicited by next-generation vaccines. Here, we use computational protein design to generate a nanoparticle vaccine platform based...
7.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Wang R, et al.
bioRxiv
. 2023 Oct;
PMID: 37781607
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by interaction with endogenous ligands. Therapeutic approaches such as LYTAC and KineTAC, have taken advantage of this to target...
8.
Ellis D, Dosey A, Boyoglu-Barnum S, Park Y, Gillespie R, Syeda H, et al.
bioRxiv
. 2023 Jun;
PMID: 37292995
Immunogen design approaches aim to control the specificity and quality of antibody responses to enable the creation of next-generation vaccines with improved potency and breadth. However, our understanding of the...
9.
Yang E, Divine R, Miranda M, Borst A, Sheffler W, Zhang J, et al.
bioRxiv
. 2023 May;
PMID: 37131615
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and important for targeted delivery of biologics. We describe the design of octahedral...
10.
Wang J, Khmelinskaia A, Sheffler W, Miranda M, Antanasijevic A, Borst A, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2214556120.
PMID: 36888664
Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would...