Sidinh Luc
Overview
Explore the profile of Sidinh Luc including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1721
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0
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Recent Articles
1.
Su T, Hauenstein J, Somuncular E, Dumral O, Leonard E, Gustafsson C, et al.
Nat Commun
. 2024 Sep;
15(1):7966.
PMID: 39261515
Age is a risk factor for hematologic malignancies. Attributes of the aging hematopoietic system include increased myelopoiesis, impaired adaptive immunity, and a functional decline of the hematopoietic stem cells (HSCs)...
2.
Somuncular E, Su T, Dumral O, Johansson A, Luc S
Stem Cells Transl Med
. 2023 Sep;
12(11):720-726.
PMID: 37706539
Hematopoiesis is maintained by hematopoietic stem cells (HSCs) that replenish all blood lineages throughout life. It is well-established that the HSC pool is functionally heterogeneous consisting of cells differing in...
3.
Gustafsson C, Hauenstein J, Frengen N, Krstic A, Luc S, Mansson R
BMC Genomics
. 2023 Apr;
24(1):205.
PMID: 37069502
Background: RNA sequencing has become the mainstay for studies of gene expression. Still, analysis of rare cells with random hexamer priming - to allow analysis of a broader range of...
4.
Somuncular E, Hauenstein J, Khalkar P, Johansson A, Dumral O, Frengen N, et al.
Stem Cell Reports
. 2022 Jun;
17(7):1546-1560.
PMID: 35714596
Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem cells (HSCs). The functional significance of HSC heterogeneity and the regulatory mechanisms underlying lineage bias are not well understood. However, absolute...
5.
Pena-Perez L, Kharazi S, Frengen N, Krstic A, Bouderlique T, Hauenstein J, et al.
Front Immunol
. 2022 May;
13:880668.
PMID: 35603175
The development of B cells relies on an intricate network of transcription factors critical for developmental progression and lineage commitment. In the B cell developmental trajectory, a temporal switch from...
6.
Smith E, Luc S, Croney D, Woodworth M, Greig L, Fujiwara Y, et al.
Blood
. 2016 Oct;
128(19):2338-2342.
PMID: 27707736
BCL11A, a repressor of human fetal (γ-)globin expression, is required for immune and hematopoietic stem cell functions and brain development. Regulatory sequences within the gene, which are subject to genetic...
7.
Luis T, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll P, et al.
Nat Immunol
. 2016 Oct;
17(12):1424-1435.
PMID: 27695000
The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear....
8.
Luc S, Huang J, McEldoon J, Somuncular E, Li D, Rhodes C, et al.
Cell Rep
. 2016 Sep;
16(12):3181-3194.
PMID: 27653684
B cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the...
9.
Canver M, Smith E, Sher F, Pinello L, Sanjana N, Shalem O, et al.
Nature
. 2015 Sep;
527(7577):192-7.
PMID: 26375006
Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in the native genomic context. Previously,...
10.
Boiers C, Carrelha J, Lutteropp M, Luc S, Green J, Azzoni E, et al.
Cell Stem Cell
. 2013 Sep;
13(5):535-48.
PMID: 24054998
In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early...