Sidhanth Chandra
Overview
Explore the profile of Sidhanth Chandra including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
268
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0
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Recent Articles
1.
Jeon S, Salvo M, Alia A, Popovic J, Zagardo M, Chandra S, et al.
Neurobiol Dis
. 2024 Nov;
202:106729.
PMID: 39515529
Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I into angiotensin II in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic...
2.
Chandra S, Vassar R
Immunol Rev
. 2024 Oct;
327(1):33-42.
PMID: 39440834
Alzheimer's disease (AD) is the most common neurodegenerative disorder and cause of dementia. Despite the prevalence of AD, there is a lack of effective disease modifying therapies. Recent evidence indicates...
3.
Chandra S, Vassar R
Neurotherapeutics
. 2024 Jul;
21(6):e00425.
PMID: 39054180
Alzheimer's disease (AD) is the most common neurodegenerative disorder and is the most common cause of dementia. AD is characterized pathologically by proteinaceous aggregates composed of amyloid beta (Aβ) and...
4.
Chandra S, Di Meco A, Dodiya H, Popovic J, Cuddy L, Weigle I, et al.
Mol Neurodegener
. 2023 Jul;
18(1):45.
PMID: 37415149
Background: Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice....
5.
Acosta M, Chandra S, Li S, Yoon E, Selgrade D, Quinn J, et al.
BMC Med Educ
. 2023 Jun;
23(1):428.
PMID: 37291579
Dual-degree MD-PhD programs have historically lacked diversity of race, ethnicity, gender, sexual orientation, and other facets of identity. Like MD- and PhD-granting programs, MD-PhD program training environments are also marked...
6.
Chandra S, Sisodia S, Vassar R
Mol Neurodegener
. 2023 Feb;
18(1):9.
PMID: 36721148
Alzheimer's disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the...
7.
Cuddy L, Alia A, Salvo M, Chandra S, Grammatopoulos T, Justman C, et al.
Mol Neurodegener
. 2022 Aug;
17(1):54.
PMID: 35987691
Background: Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles...
8.
Di Meco A, Kemal S, Popovic J, Chandra S, Sadleir K, Vassar R
Curr Alzheimer Res
. 2022 May;
19(4):317-329.
PMID: 35579170
Background: Alzheimer's disease (AD) is initiated by aberrant accumulation of amyloid beta (Aβ) protein in the brain parenchyma. The microenvironment surrounding amyloid plaques is characterized by the swelling of presynaptic...
9.
Xu E, Boddu R, Abdelmotilib H, Sokratian A, Kelly K, Liu Z, et al.
Mol Neurodegener
. 2022 Jan;
17(1):7.
PMID: 35012605
Background: Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson's disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammatory...
10.
Underwood R, Gannon M, Pathak A, Kapa N, Chandra S, Klop A, et al.
Acta Neuropathol Commun
. 2021 Jan;
9(1):13.
PMID: 33413679
Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson's Disease (PD) and Dementia with Lewy...