Siddharthan Chandran
Overview
Explore the profile of Siddharthan Chandran including associated specialties, affiliations and a list of published articles.
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245
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7530
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Recent Articles
11.
Blackstone J, Williams T, Nicholas J, Bordea E, De Angelis F, Bianchi A, et al.
BMJ Open
. 2024 Sep;
14(9):e086414.
PMID: 39284697
Introduction: There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study,...
12.
Dando O, McQueen J, Burr K, Kind P, Chandran S, Hardingham G, et al.
Front Mol Neurosci
. 2024 Sep;
17:1392408.
PMID: 39268251
Rodent studies have shown that alternative splicing in neurons plays important roles in development and maturity, and is regulatable by signals such as electrical activity. However, rodent-human similarities are less...
13.
John N, Li Y, De Angelis F, Stutters J, Carrasco F, Eshaghi A, et al.
BMJ Neurol Open
. 2024 Sep;
6(2):e000670.
PMID: 39262426
Background: The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain...
14.
Dando O, McGeachan R, McQueen J, Baxter P, Rockley N, McAlister H, et al.
Neuropathol Appl Neurobiol
. 2024 Aug;
50(4):e13006.
PMID: 39164997
Aims: Mutations in the MAPT gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer's disease, the most common tauopathy, synapse loss...
15.
Bonthron C, Burley S, Broadhead M, Metodieva V, Grant S, Chandran S, et al.
PLoS One
. 2024 Aug;
19(8):e0306423.
PMID: 39088455
Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes in the relative amount of excitatory to...
16.
Reid K, Beswick E, Tam J, Symonds A, Lyle D, Newton J, et al.
J Neurol Sci
. 2024 Jun;
462:123072.
PMID: 38885541
Background: Digital technology offers individuals the opportunity to monitor their symptoms. Information gathered from apps, devices, and web platforms may be used to direct clinical care and to support research....
17.
Leighton D, Ansari M, Newton J, Cleary E, Stephenson L, Beswick E, et al.
J Neurol
. 2024 Jun;
271(8):5256-5266.
PMID: 38852112
Background: Using the Clinical Audit Research and Evaluation of Motor Neuron Disease (CARE-MND) database and the Scottish Regenerative Neurology Tissue Bank, we aimed to outline the genetic epidemiology and phenotypes...
18.
Beswick E, Christides A, Symonds A, Johnson M, Fawcett T, Newton J, et al.
J Neurol
. 2024 May;
271(8):5083-5101.
PMID: 38805054
Motor neuron disease (MND) is a rapidly progressive condition traditionally assessed using a questionnaire to evaluate physical function, the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). Its use can...
19.
Salzinger A, Ramesh V, Das Sharma S, Chandran S, Selvaraj B
Cells
. 2024 May;
13(10.
PMID: 38786016
The primary neural circuit affected in Amyotrophic Lateral Sclerosis (ALS) patients is the corticospinal motor circuit, originating in upper motor neurons (UMNs) in the cerebral motor cortex which descend to...
20.
Dando O, McGeachan R, McQueen J, Baxter P, Rockley N, McAlister H, et al.
medRxiv
. 2024 Apr;
PMID: 38645146
Mutations in the gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer's disease, the most common tauopathy, synapse loss is the...