Siddhartha Mondragon-Rodriguez
Overview
Explore the profile of Siddhartha Mondragon-Rodriguez including associated specialties, affiliations and a list of published articles.
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17
Citations
536
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Recent Articles
1.
Garcia-Carlos C, Basurto-Islas G, Perry G, Mondragon-Rodriguez S
J Alzheimers Dis
. 2024 Apr;
99(2):595-607.
PMID: 38669540
Background: Cognitive deficits observed in Alzheimer's disease (AD) patients have been correlated with altered hippocampal activity. Although the mechanism remains under extensive study, neurofibrillary tangles and amyloid plaques have been...
2.
Xolalpa-Cueva L, Garcia-Carlos C, Villasenor-Zepeda R, Orta-Salazar E, Diaz-Cintra S, Pena-Ortega F, et al.
J Alzheimers Dis
. 2022 Mar;
87(2):529-543.
PMID: 35342085
Background: Tau hyperphosphorylation at several sites, including those close to its microtubule domain (MD), is considered a key pathogenic event in the development of tauopathies. Nevertheless, we recently demonstrated that...
3.
Mondragon-Rodriguez S, Ordaz B, Orta-Salazar E, Diaz-Cintra S, Pena-Ortega F, Perry G
Bio Protoc
. 2021 Mar;
10(4):e3529.
PMID: 33654753
Transgenic mice have been used to make valuable contributions to the field of neuroscience and model neurological diseases. The simultaneous functional analysis of hippocampal cell activity combined with hippocampal dependent...
4.
Mondragon-Rodriguez S, Salgado-Burgos H, Pena-Ortega F
Neural Plast
. 2020 Sep;
2020:2960343.
PMID: 32952546
For more than five decades, the field of Alzheimer's disease (AD) has focused on two main hypotheses positing amyloid-beta (A) and Tau phosphorylation (pTau) as key pathogenic mediators. In line...
5.
Mondragon-Rodriguez S, Gu N, Fasano C, Pena-Ortega F, Williams S
Neuroscience
. 2019 Jan;
401:96-105.
PMID: 30599271
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits. Brain...
6.
Mondragon-Rodriguez S, Gu N, Manseau F, Williams S
Front Cell Neurosci
. 2018 Jun;
12:121.
PMID: 29867356
Alzheimer's disease (AD) is defined by the presence of amyloid-β (Aβ) and tau protein aggregates. However, increasing data is suggesting that brain network alterations rather than protein deposition could account...
7.
Mondragon-Rodriguez S, Salas-Gallardo A, Gonzalez-Pereyra P, Macias M, Ordaz B, Pena-Ortega F, et al.
J Biol Chem
. 2018 Apr;
293(22):8462-8472.
PMID: 29632073
Tau hyperphosphorylation at several sites, including those close to the microtubule domain region (MDr), is considered a key pathological event in the development of Alzheimer's disease (AD). Recent studies indicate...
8.
Mahar I, Albuquerque M, Mondragon-Rodriguez S, Cavanagh C, Davoli M, Chabot J, et al.
Front Aging Neurosci
. 2017 Feb;
8:327.
PMID: 28154533
Interneurons, key regulators of hippocampal neuronal network excitability and synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that network changes occur at early (presymptomatic) stages, we explored...
9.
Mondragon-Rodriguez S, Perry G, Pena-Ortega F, Williams S
Curr Alzheimer Res
. 2016 Aug;
14(1):40-46.
PMID: 27539594
Background: The last two decades have seen a great advance in the data that supports the two current hypotheses in Alzheimer`s disease field, the amyloid beta hypothesis and the tau...
10.
Zhang F, Su B, Wang C, Siedlak S, Mondragon-Rodriguez S, Lee H, et al.
Transl Neurodegener
. 2015 Jun;
4:9.
PMID: 26029362
Background: In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in microtubules in pyramidal neurons in...