Siddharth Sukumaran
Overview
Explore the profile of Siddharth Sukumaran including associated specialties, affiliations and a list of published articles.
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41
Citations
927
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Recent Articles
1.
Seth N, Xu R, DuPrie M, Choudhury A, Sihapong S, Tyler S, et al.
MAbs
. 2025 Feb;
17(1):2461191.
PMID: 39936406
Nipocalimab is a human immunoglobulin G (IgG)1 monoclonal antibody that binds to the neonatal Fc receptor (FcRn) with high specificity and high affinity at both neutral (extracellular) and acidic (intracellular)...
2.
Schachner L, Mullen C, Phung W, Hinkle J, Beardsley M, Bentley T, et al.
Nat Commun
. 2024 Apr;
15(1):3259.
PMID: 38627419
The heterogeneity inherent in today's biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule's safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality...
3.
Tao X, Sukumaran S, Sperinde G, Liu C, Beardsley M, Day P, et al.
J Pharm Sci
. 2024 Apr;
113(7):1975-1986.
PMID: 38561054
Sialic acid (SA) is crucial for protecting glycoproteins from clearance. Efmarodocokin alfa (IL-22Fc), a fusion protein agonist that links IL-22 to the crystallizable fragment (Fc) of human IgG4, contains 8...
4.
Yadav R, Sukumaran S, Lutman J, Mitra M, Halpern W, Sun T, et al.
J Pharm Sci
. 2023 Jul;
112(11):2910-2920.
PMID: 37429356
MTBT1466A is a high-affinity TGFβ3-specific humanized IgG1 monoclonal antibody with reduced Fc effector function, currently under investigation in clinical trials as a potential anti-fibrotic therapy. Here, we characterized the pharmacokinetics...
5.
Rymut S, Henderson L, Poon V, Staton T, Cai F, Sukumaran S, et al.
Clin Transl Sci
. 2023 Feb;
16(4):694-703.
PMID: 36755366
Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by...
6.
Gadkar K, Feigelman J, Sukumaran S, Rodrigo M, Staton T, Cai F, et al.
CPT Pharmacometrics Syst Pharmacol
. 2022 Jul;
11(9):1268-1277.
PMID: 35857704
Asthma is a complex, heterogeneous disease with a high unmet medical need, despite therapies targeting a multitude of pathways. The ability to quantitatively integrate preclinical and clinical data on these...
7.
Yadav R, Sukumaran S, Zabka T, Li J, Oldendorp A, Morrow G, et al.
Pharmaceutics
. 2022 May;
14(5).
PMID: 35631556
The T cell-dependent bispecific (TDB) antibody, anti-CD79b/CD3, targets CD79b and CD3 cell-surface receptors expressed on B cells and T cells, respectively. Since the anti-CD79b arm of this TDB binds only...
8.
Rymut S, Sukumaran S, Sperinde G, Bremer M, Galanter J, Yoshida K, et al.
Clin Transl Sci
. 2021 Sep;
15(2):451-463.
PMID: 34581002
Tryptase is the most abundant secretory granule protein in human lung mast cells and plays an important role in asthma pathogenesis. MTPS9579A is a novel monoclonal antibody that selectively inhibits...
9.
Sun T, Huang Z, Liang W, Yin J, Lin W, Wu J, et al.
Sci Transl Med
. 2021 Aug;
13(605).
PMID: 34349032
Transforming growth factor-β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms (TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; however, the postnatal pathological roles...
10.
Ayyar V, Sukumaran S
J Pharmacokinet Pharmacodyn
. 2021 Apr;
48(3):321-338.
PMID: 33797011
Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining, entrainable, and oscillatory manner, and orchestrate a wide range of molecular, physiological, and behavioral processes. Circadian clocks are comprised...