Siddarth Chandrasekaran
Overview
Explore the profile of Siddarth Chandrasekaran including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
371
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Recent Articles
1.
Tariq D, Maurici N, Bartholomai B, Chandrasekaran S, Dunlap J, Bah A, et al.
Elife
. 2024 Mar;
12.
PMID: 38526948
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus the proteins requency (RQ), the RQ-interacting RNA...
2.
Hersch S, Chandrasekaran S, Lam J, Nafissi N, Slavcev R
Mol Ther Methods Clin Dev
. 2024 Mar;
32(2):101227.
PMID: 38516691
Biotechnologies such as gene therapy have brought DNA vectors to the forefront of pharmaceuticals. The quality of starting material plays a pivotal role in determining final product quality. Here, we...
3.
Maschmann Z, Chandrasekaran S, Chua T, Crane B
Biochemistry
. 2022 Nov;
61(23):2672-2686.
PMID: 36321948
Bacterial chemoreceptors regulate the cytosolic multidomain histidine kinase CheA through largely unknown mechanisms. Residue substitutions in the peptide linkers that connect the P4 kinase domain to the P3 dimerization and...
4.
Maschmann Z, Chua T, Chandrasekaran S, Ibanez H, Crane B
J Biol Chem
. 2022 Oct;
298(12):102598.
PMID: 36252616
The Per-Arnt-Sim (PAS; named for the representative proteins: Period, Aryl hydrocarbon receptor nuclear translocator protein and Single-minded) domain of the dimeric Escherichia coli aerotaxis receptor Aer monitors cellular respiration through...
5.
DSouza A, Marshall L, Yoon J, Kulesha A, Edirisinghe D, Chandrasekaran S, et al.
Nano Converg
. 2022 Apr;
9(1):18.
PMID: 35478076
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable...
6.
Lin C, Schneps C, Chandrasekaran S, Ganguly A, Crane B
Structure
. 2022 Apr;
30(6):851-861.e5.
PMID: 35397203
Cryptochrome (CRY) entrains the fly circadian clock by binding to Timeless (TIM) in light. Undocking of a helical C-terminal tail (CTT) in response to photoreduction of the CRY flavin cofactor...
7.
Maurer M, Lewis K, Kuijper J, Ardourel D, Gudgeon C, Chandrasekaran S, et al.
Nat Commun
. 2022 Apr;
13(1):1790.
PMID: 35379805
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy....
8.
Zhang Y, Su D, Dzikovski B, Majer S, Coleman R, Chandrasekaran S, et al.
J Am Chem Soc
. 2021 Jun;
143(25):9314-9319.
PMID: 34154323
All radical -adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1-Dph2, require at least one [4Fe-4S](Cys) cluster for activity. It is well-known in the radical-SAM enzyme community...
9.
Chandrasekaran S, Schneps C, Dunleavy R, Lin C, DeOliveira C, Ganguly A, et al.
Commun Biol
. 2021 Feb;
4(1):249.
PMID: 33637846
Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM). Specific peptide...
10.
Dzikovski B, Khramtsov V, Chandrasekaran S, Dunnam C, Shah M, Freed J
J Am Chem Soc
. 2020 Dec;
142(51):21368-21381.
PMID: 33305945
Exchange processes which include conformational change, protonation/deprotonation, and binding equilibria are routinely studied by 2D exchange NMR techniques, where information about the exchange of nuclei between environments with different NMR...