Shunichi Shimizu
Overview
Explore the profile of Shunichi Shimizu including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
1359
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Recent Articles
1.
Sakaguchi R, Takahashi N, Yoshida T, Ogawa N, Ueda Y, Hamano S, et al.
J Biol Chem
. 2024 Aug;
300(9):107705.
PMID: 39178948
The cell signaling molecules nitric oxide (NO) and Ca regulate diverse biological processes through their closely coordinated activities directed by signaling protein complexes. However, it remains unclear how dynamically the...
2.
Yamamoto S, Kiyatake N, Kaneko A, Shimamura M, Yoshida T, Shimizu S
Genes Cells
. 2024 Jan;
29(3):254-269.
PMID: 38247314
Transient receptor potential melastatin 2 (TRPM2) assembles into tetramers to function as an oxidative stress-sensitive Ca channel at the surface membrane. Limited information is currently available on the 10 protein...
3.
Ishibashi M, Ishii M, Yamamoto S, Mori Y, Shimizu S
Eur J Pharmacol
. 2020 Nov;
891:173671.
PMID: 33131720
Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca-permeable channel. The activation of TRPM2 by HO causes cell death in various types of cells. 5-Fluorouracil (5-FU) is an...
4.
Yamamoto S, Ishii T, Mikami R, Numata T, Shimizu S
Biochem Biophys Res Commun
. 2019 Oct;
520(3):520-525.
PMID: 31610913
Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD)....
5.
Toda T, Yamamoto S, Umehara N, Mori Y, Wakamori M, Shimizu S
J Pharmacol Exp Ther
. 2018 Dec;
368(2):246-254.
PMID: 30523061
Activation of transient receptor potential melastatin 2 (TRPM2), an oxidative stress-sensitive Ca-permeable channel, contributes to the aggravation of cerebral ischemia-reperfusion (CIR) injury. Recent studies indicated that treatment with the antidepressant...
6.
Yamamoto S, Toda T, Yonezawa R, Negoro T, Shimizu S
J Pharmacol Sci
. 2017 May;
134(1):68-74.
PMID: 28532624
Purpose: TRPM2 is a Ca-permeable channel that is activated by HO. TRPM2-mediated Ca signaling has been implicated in the aggravation of inflammatory diseases. Therefore, the development of TRPM2 inhibitors to...
7.
Yamamoto S, Shimizu S
Eur J Pharmacol
. 2016 Nov;
793:109-111.
PMID: 27838397
Reactive oxygen species induce oxidative stress, leading to cell damage, but also function as signal transduction molecules. Transient receptor potential (TRP) channels have been attracting increasing attention as Ca-permeable channels...
8.
Yamamoto S, Shimizu S
Pharmaceuticals (Basel)
. 2016 Sep;
9(3).
PMID: 27618067
Under pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease. The...
9.
Toda T, Yamamoto S, Yonezawa R, Mori Y, Shimizu S
Eur J Pharmacol
. 2016 May;
786:19-28.
PMID: 27238971
Some transient receptor potential (TRP) proteins including TRPA1, TPRM2 and TRPV1 are oxidative stress-sensitive Ca(2+)-permeable channels. Ca(2+) signaling via these TRP channels activated by oxidative stress has been implicated in...
10.
Yonezawa R, Yamamoto S, Takenaka M, Kage Y, Negoro T, Toda T, et al.
Free Radic Biol Med
. 2015 Nov;
90:101-13.
PMID: 26600069
Lung inflammation is a major adverse effect of therapy with the antitumor drug bleomycin (BLM). Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable channel that is activated by oxidative...