Shuichi Sakai
Overview
Explore the profile of Shuichi Sakai including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
759
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Recent Articles
1.
Ikezoe T, Bandobashi K, Yang Y, Takeuchi S, Sekiguchi N, Sakai S, et al.
Leuk Res
. 2006 Feb;
30(8):1005-11.
PMID: 16457885
HIV-1 protease inhibitor, ritonavir (RTV) is a potent inhibitor of cytochrome p450 (CYPs) enzymes. This study explored the effects of RTV on CYP24 which converts 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] to its...
2.
Iwasaki M, Yoshimura Y, Asahi S, Saito K, Sakai S, Morita S, et al.
Drug Metab Pharmacokinet
. 2005 Feb;
19(6):444-52.
PMID: 15681899
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of...
3.
Mizuma T, Kawashima K, Sakai S, Sakaguchi S, Hayashi M
J Pharm Sci
. 2005 Jan;
94(3):571-5.
PMID: 15666320
The impact of intestinal conjugative metabolism on oral bioavailability was assessed by sequential and simultaneous analyses of the reported data in humans. The data were retrieved from reports on drugs...
4.
Kawamura T, Omura S, Sakai S, Yamashita I
Zoolog Sci
. 2003 Feb;
20(1):43-7.
PMID: 12560600
In order to elucidate a possible role of estrogen receptor in the gonadal sex differentiation and the sex reversal with sex steroids, we examined for the formation of testis or...
5.
Kawamura T, Sakai S, Omura S, Hori-e R, Kawahara T, Kinoshita M, et al.
Zoolog Sci
. 2003 Jan;
19(12):1355-61.
PMID: 12520095
We established three transgenic medaka fish lines overexpressing the medaka estrogen receptor under the constitutive medaka beta-actin promoter. The transgenic embryos became hypersensitive to estrogens (17 beta-estradiol and 17alpha-ethinylestradiol), and...
6.
Akiyama T, Baumann C, Sakai S, Hager G, Gonzalez F
Mol Endocrinol
. 2002 Mar;
16(4):707-21.
PMID: 11923467
The intracellular localization of transcriptionally active green fluorescent protein (GFP) chimeras linked to PPARs for human PPAR alpha (GFP-PPARh alpha) and mouse PPAR alpha, beta, and gamma 1 (GFP-PPARm alpha,...
7.
Akiyama T, Sakai S, Lambert G, Nicol C, Matsusue K, Pimprale S, et al.
Mol Cell Biol
. 2002 Mar;
22(8):2607-19.
PMID: 11909955
Disruption of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene causes embryonic lethality due to placental dysfunction. To circumvent this, a PPAR gamma conditional gene knockout mouse was produced by...
8.
Rosen E, Hsu C, Wang X, Sakai S, Freeman M, Gonzalez F, et al.
Genes Dev
. 2002 Jan;
16(1):22-6.
PMID: 11782441
PPARgamma and C/EBPalpha are critical transcription factors in adipogenesis, but the precise role of these proteins has been difficult to ascertain because they positively regulate each other's expression. Questions remain...