Shubh Sharma
Overview
Explore the profile of Shubh Sharma including associated specialties, affiliations and a list of published articles.
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5
Citations
363
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0
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Recent Articles
1.
Yeo G, Herrera Moro Chao D, Siegert A, Koerperich Z, Ericson M, Simonds S, et al.
Mol Metab
. 2021 Mar;
48:101206.
PMID: 33684608
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption...
2.
Sharma S, Garfield A, Shah B, Kleyn P, Ichetovkin I, Moeller I, et al.
Molecules
. 2019 May;
24(10).
PMID: 31100979
In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R. Delineation of cellular...
3.
Clement K, Biebermann H, Farooqi I, van der Ploeg L, Wolters B, Poitou C, et al.
Nat Med
. 2018 May;
24(5):551-555.
PMID: 29736023
Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to severe obesity. Three severely obese LEPR-deficient individuals were administered the MC4R agonist setmelanotide, resulting in substantial and durable reductions...
4.
Collet T, Dubern B, Mokrosinski J, Connors H, Keogh J, Mendes de Oliveira E, et al.
Mol Metab
. 2017 Oct;
6(10):1321-1329.
PMID: 29031731
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in...
5.
Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131
van der Ploeg L, Laken H, Sharma S, Datta R, Halem H, Dong J, et al.
Life Sci
. 2014 Jun;
109(1):20-9.
PMID: 24931905
Aims: The 28 amino acid hormone ghrelin, the natural ligand for the growth hormone secretagogue, or ghrelin receptor (GHR), has diverse physiological functions, including a possible role as a gastrointestinal...