Shomit Sengupta
Overview
Explore the profile of Shomit Sengupta including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
3625
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Recent Articles
1.
Flores E, Tsai K, Crowley D, Sengupta S, Yang A, McKeon F, et al.
Nature
. 2024 Feb;
627(8004):E10.
PMID: 38418890
No abstract available.
2.
Kang S, ONeill D, Machl A, Lumpkin C, Galda S, Sengupta S, et al.
Cell Chem Biol
. 2019 Jun;
26(9):1203-1213.e13.
PMID: 31231029
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its...
3.
Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, ONeill D, et al.
Sci Rep
. 2019 Mar;
9(1):4107.
PMID: 30858438
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including...
4.
Yilmaz O, Katajisto P, Lamming D, Gultekin Y, Bauer-Rowe K, Sengupta S, et al.
Nature
. 2012 Jun;
486(7404):490-5.
PMID: 22722868
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the...
5.
Lindquist R, Ottina K, Wheeler D, Hsu P, Thoreen C, Guertin D, et al.
Genome Res
. 2011 Jan;
21(3):433-46.
PMID: 21239477
The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1...
6.
Sengupta S, Peterson T, Laplante M, Oh S, Sabatini D
Nature
. 2010 Dec;
468(7327):1100-4.
PMID: 21179166
The multi-component mechanistic target of rapamycin complex 1 (mTORC1) kinase is the central node of a mammalian pathway that coordinates cell growth with the availability of nutrients, energy and growth...
7.
Sengupta S, Peterson T, Sabatini D
Mol Cell
. 2010 Oct;
40(2):310-22.
PMID: 20965424
The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms...
8.
Lin Y, Sengupta S, Gurdziel K, Bell G, Jacks T, Flores E
PLoS Genet
. 2009 Oct;
5(10):e1000680.
PMID: 19816568
The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development...
9.
Klumpp D, Rycyk M, Chen M, Thumbikat P, Sengupta S, Schaeffer A
Infect Immun
. 2006 Aug;
74(9):5106-13.
PMID: 16926402
A murine model of urinary tract infection identified urothelial apoptosis as a key event in the pathogenesis mediated by uropathogenic Escherichia coli (UPEC), yet the mechanism of this important host...
10.
Sarbassov D, Ali S, Sengupta S, Sheen J, Hsu P, Bagley A, et al.
Mol Cell
. 2006 Apr;
22(2):159-68.
PMID: 16603397
The drug rapamycin has important uses in oncology, cardiology, and transplantation medicine, but its clinically relevant molecular effects are not understood. When bound to FKBP12, rapamycin interacts with and inhibits...