Shoichi Date
Overview
Explore the profile of Shoichi Date including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1600
Followers
0
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Recent Articles
1.
Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, et al.
Nature
. 2019 Dec;
577(7789):254-259.
PMID: 31853059
With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations. However, whether such clonal expansion exists in the non-neoplastic intestine remains unknown. Here, using whole-exome...
2.
Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, et al.
Cell Stem Cell
. 2018 Jan;
22(2):171-176.e5.
PMID: 29290616
Genetic lineage tracing has revealed that Lgr5 murine colon stem cells (CoSCs) rapidly proliferate at the crypt bottom. However, the spatiotemporal dynamics of human CoSCs in vivo have remained experimentally...
3.
Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, et al.
Nature
. 2017 Mar;
545(7653):187-192.
PMID: 28355176
The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells that fuels tumour growth. The existence of human CSCs is mainly supported by xenotransplantation of prospectively isolated...
4.
Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, et al.
Cell Stem Cell
. 2016 May;
18(6):827-838.
PMID: 27212702
Colorectal tumor is a heterogeneous disease, with varying clinical presentation and prognosis in patients. To establish a platform encompassing this diversity, we generated 55 colorectal tumor organoid lines from a...
5.
Date S, Sato T
Annu Rev Cell Dev Biol
. 2015 Oct;
31:269-89.
PMID: 26436704
In the adult mammalian body, self-renewal of tissue stem cells is regulated by extracellular niche environments in response to the demands of tissue organization. Intestinal stem cells expressing Lgr5 constantly...
6.
Matano M, Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, et al.
Nat Med
. 2015 Feb;
21(3):256-62.
PMID: 25706875
Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in the WNT, MAPK, TGF-β, TP53 and PI3K pathways. Although these pathways influence intestinal stem cell niche signaling, the...
7.
Yoda N, Emoto C, Date S, Kondo S, Miyake M, Nakazato S, et al.
Xenobiotica
. 2012 Feb;
42(8):719-30.
PMID: 22324396
Cynomolgus monkeys are widely used to predict human pharmacokinetic and/or toxic profiles in the drug developmental stage. Characterization of cynomolgus monkey P450s such as the mRNA expression level, substrate specificity,...
8.
Oishi T, Date S, Shimamoto Y, Saito T, Hirota K, Sugaya T, et al.
J Recept Signal Transduct Res
. 2010 Aug;
30(6):484-92.
PMID: 20684663
Angiotensinogen (AGT), mainly produced in the liver, is the precursor of angiotensin II, an important regulator of blood pressure and electrolyte homeostasis. We previously showed, in hepatoma-derived HepG2 cells that...
9.
Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A
Int J Mol Med
. 2004 Apr;
13(5):637-42.
PMID: 15067362
We previously identified a regulatory element at the 3'-downstream region of the human angiotensinogen (hANG) gene. Using this element as a probe by the Southwestern screening, we isolated a cDNA...