Shirley M H Sy
Overview
Explore the profile of Shirley M H Sy including associated specialties, affiliations and a list of published articles.
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8
Citations
711
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Recent Articles
1.
Dong C, West K, Tan X, Li J, Ishibashi T, Yu C, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(29):17019-17030.
PMID: 32611815
DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability. We screened a chemical library designed to target the human kinome for...
2.
Guo Y, An L, Ng H, Sy S, Huen M
J Biol Chem
. 2016 Dec;
292(3):967-978.
PMID: 27903633
Protein ubiquitination has emerged as a pivotal regulatory reaction that promotes cellular responses to DNA damage. With a goal to delineate the DNA damage signal transduction cascade, we systematically analyzed...
3.
Guo Y, Feng W, Sy S, Huen M
J Biol Chem
. 2015 Oct;
290(46):27545-56.
PMID: 26420486
The Fanconi anemia protein PALB2, also known as FANCN, protects genome integrity by regulating DNA repair and cell cycle checkpoints. Exactly how PALB2 functions may be temporally coupled with detection...
4.
Sy S, Jiang J, O W, Deng Y, Huen M
Nucleic Acids Res
. 2013 Jul;
41(18):8572-80.
PMID: 23863847
Ubiquitylation plays key roles in DNA damage signal transduction. The current model envisions that lysine63-linked ubiquitin chains, via the concerted action of E3 ubiquitin ligases RNF8-RNF168, are built at DNA...
5.
Huen M, Sy S, Leung K, Ching Y, Tipoe G, Man C, et al.
Cell Cycle
. 2010 Jun;
9(13):2679-85.
PMID: 20581448
The eukaryotic RNA splicing machinery is dedicated to the daunting task of excising intronic sequences on the many nascent RNA transcripts in a cell, and in doing so facilitates proper...
6.
Huen M, Sy S, Chen J
Nat Rev Mol Cell Biol
. 2009 Dec;
11(2):138-48.
PMID: 20029420
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through...
7.
Sy S, Huen M, Chen J
Proc Natl Acad Sci U S A
. 2009 Apr;
106(17):7155-60.
PMID: 19369211
Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer development. We previously reported an in vivo interaction between BRCA1 and...
8.
Sy S, Wong N, Mok T, Tsao M, Lee T, Tse G, et al.
Lung Cancer
. 2003 Jun;
41(1):91-9.
PMID: 12826317
Adenocarcinoma of the lung is now the most common histologic subtype of non-small-cell lung cancer (NSCLC) worldwide. In Chinese populations, the incidence of lung adenocarcinoma is amongst the highest worldwide...