Shin-Ai Lee
Overview
Explore the profile of Shin-Ai Lee including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
11
Citations
175
Followers
0
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Recent Articles
1.
Xiang R, Lee S, Tyndall C, Bhatia A, Yin J, Singler C, et al.
Cell Rep
. 2025 Feb;
44(2):115312.
PMID: 39954255
Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is co-amplified...
2.
Kwon J, Lee D, Lee S
Exp Mol Med
. 2023 Apr;
55(4):745-754.
PMID: 37009801
BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide array of biological activities. Studies in which advanced sequencing technologies were used have uncovered a link between BAP1 and...
3.
Kang M, Park S, Lee S, Kim S, Lee D, Shirbhate M, et al.
Sci Rep
. 2023 Feb;
13(1):2264.
PMID: 36754982
BRCA1-associated protein-1 (BAP1) is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase. The gene encoding BAP1 is mutated in various human cancers, including mesothelioma, uveal melanoma and renal cell carcinoma. BAP1 plays...
4.
Lee S, Lee D, Kang M, Kim S, Kwon S, Lee H, et al.
Cell Death Differ
. 2022 May;
29(12):2381-2398.
PMID: 35637285
BRCA1-associated protein-1 (BAP1) is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with tumor suppressor activity. The gene encoding BAP1 is mutated in various human cancers, with particularly high frequency in kidney...
5.
Seo H, Jeong D, Lee S, Lee H, Lee S, Kang S, et al.
Mol Cells
. 2021 Mar;
44(2):101-115.
PMID: 33658435
The INO80 chromatin remodeling complex has roles in many essential cellular processes, including DNA replication. However, the mechanisms that regulate INO80 in these processes remain largely unknown. We previously reported...
6.
Lee D, Lee D, Hwang Y, Seo H, Lee S, Kwon J
Mol Cancer Res
. 2020 Nov;
19(5):900-912.
PMID: 33208498
Many chemotherapeutic drugs produce double-strand breaks (DSB) on cancer cell DNA, thereby inducing cell death. However, the DNA damage response (DDR) enables cancer cells to overcome DNA damage and escape...
7.
Park S, Lee D, Seo H, Lee S, Kwon J
Sci Rep
. 2020 Oct;
10(1):16330.
PMID: 33004947
Bromodomain (BRD), a protein module that recognizes acetylated lysine residues on histones and other proteins, has recently emerged as a promising therapeutic target for human diseases such as cancer. While...
8.
Lee H, Seo H, Lee S, Choi S, Kang D, Kwon J
Biochem J
. 2019 Oct;
476(20):3053-3066.
PMID: 31657441
The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that...
9.
Lee S, Lee H, Hur S, Kang S, Oh G, Lee D, et al.
Oncotarget
. 2018 Feb;
8(70):115041-115053.
PMID: 29383140
The INO80 chromatin-remodeling complex performs functions in many chromosomal processes that are crucial for genome stability, such as DNA replication and stalled replication fork recovery. Although these functions suggest that...
10.
Kwon S, Lee S, Na J, Lee S, Lee H, Park J, et al.
Mol Cancer Ther
. 2014 Dec;
14(2):597-607.
PMID: 25504753
Radiotherapy treats cancer by inducing DNA double-strand breaks (DSB) in tumor cells using ionizing radiation. However, DNA repair in tumor cells often leads to radioresistance and unsuccessful outcome. Inhibition of...