Shimyn Slomovic
Overview
Explore the profile of Shimyn Slomovic including associated specialties, affiliations and a list of published articles.
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17
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1117
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Recent Articles
1.
Nguyen P, Soenksen L, Donghia N, Angenent-Mari N, de Puig H, Huang A, et al.
Nat Biotechnol
. 2021 Jun;
39(11):1366-1374.
PMID: 34183860
Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits generally requires...
2.
Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(47):23505-23511.
PMID: 31685628
Comorbidity is common as age increases, and currently prescribed treatments often ignore the interconnectedness of the involved age-related diseases. The presence of any one such disease usually increases the risk...
3.
Lee J, Chan C, Slomovic S, Collins J
Nat Chem Biol
. 2018 May;
14(6):530-537.
PMID: 29769737
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant...
4.
Pardee K, Slomovic S, Nguyen P, Lee J, Donghia N, Burrill D, et al.
Cell
. 2016 Sep;
167(1):248-259.e12.
PMID: 27662092
Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeutic proteins, and other commodities. However, the need for specialized equipment and refrigeration for production and distribution...
5.
Slomovic S, Pardee K, Collins J
Proc Natl Acad Sci U S A
. 2015 Nov;
112(47):14429-35.
PMID: 26598662
There is a growing need to enhance our capabilities in medical and environmental diagnostics. Synthetic biologists have begun to focus their biomolecular engineering approaches toward this goal, offering promising results...
6.
Slomovic S, Collins J
Nat Methods
. 2015 Sep;
12(11):1085-90.
PMID: 26389572
We generated synthetic protein components that can detect specific DNA sequences and subsequently trigger a desired intracellular response. These modular sensors exploit the programmability of zinc-finger DNA recognition to drive...
7.
Slomovic S, Schuster G
Methods Enzymol
. 2013 Sep;
530:227-51.
PMID: 24034325
Many techniques that are used to characterize individual RNA molecules can potentially alter the original transcript sequence or its posttranscriptional modifications, such as polyadenylation. Methods that are designed to define...
8.
Slomovic S, Schuster G
Methods Enzymol
. 2013 Sep;
530:209-26.
PMID: 24034324
The posttranscriptional modification of RNA by polyadenylation serves various purposes, among them to assist in RNA degradation (see an alternative protocol for measuring RNA degradation on Method for measuring mRNA...
9.
Kalghatgi S, Spina C, Costello J, Liesa M, Morones-Ramirez J, Slomovic S, et al.
Sci Transl Med
. 2013 Jul;
5(192):192ra85.
PMID: 23825301
Prolonged antibiotic treatment can lead to detrimental side effects in patients, including ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms underlying the effects of antibiotics in mammalian systems remain unclear. It...
10.
Slomovic S, Schuster G
Wiley Interdiscip Rev RNA
. 2011 Sep;
2(1):106-23.
PMID: 21956972
RNA polyadenylation occurs in most forms of life, excluding a small number of biological systems. This posttranscriptional modification undertakes two roles, both of which influence the stability of the polyadenylated...