Shigehiro A Kawashima
Overview
Explore the profile of Shigehiro A Kawashima including associated specialties, affiliations and a list of published articles.
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36
Citations
1330
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Recent Articles
1.
Yamanashi Y, Takamaru S, Okabe A, Kaito S, Azumaya Y, Kamimura Y, et al.
Nat Commun
. 2025 Jan;
16(1):887.
PMID: 39856033
The number and variety of identified histone post-translational modifications (PTMs) are continually increasing. However, the specific consequences of each histone PTM remain largely unclear, primarily due to the lack of...
2.
Fukuta T, Tatsumi T, Fujiyoshi K, Koyama T, Kawashima S, Mitsunuma H, et al.
Org Lett
. 2024 Oct;
26(41):8827-8831.
PMID: 39387660
Phosphorylated tyrosine is a fundamental building block of bioactive peptides and proteins. However, the chemoselective phosphorylation of tyrosine over other nucleophilic amino acid residues in unprotected peptides remains a significant...
3.
Umeda H, Suda K, Yokogawa D, Azumaya Y, Kitada N, Maki S, et al.
Angew Chem Int Ed Engl
. 2024 May;
63(31):e202405605.
PMID: 38757875
Pathogenic protein aggregates, called amyloids, are etiologically relevant to various diseases, including neurodegenerative Alzheimer disease. Catalytic photooxygenation of amyloids, such as amyloid-β (Aβ), reduces their toxicity; however, the requirement for...
4.
Furuta M, Arii S, Umeda H, Matsukawa R, Shizu K, Kaji H, et al.
Adv Sci (Weinh)
. 2024 May;
11(26):e2401346.
PMID: 38689504
Aberrant aggregates of amyloid-β (Aβ) and tau protein (tau), called amyloid, are related to the etiology of Alzheimer disease (AD). Reducing amyloid levels in AD patients is a potentially effective...
5.
Fujimura A, Ishida H, Nozaki T, Terada S, Azumaya Y, Ishiguro T, et al.
ACS Cent Sci
. 2023 Nov;
9(11):2115-2128.
PMID: 38033808
Peptides are privileged ligands for diverse biomacromolecules, including proteins; however, their utility is often limited due to low membrane permeability and in-cell instability. Here, we report peptide ligand-inserted eDHFR (PLIED)...
6.
Habazaki M, Mizumoto S, Kajino H, Kujirai T, Kurumizaka H, Kawashima S, et al.
Nat Commun
. 2023 Sep;
14(1):5790.
PMID: 37737243
Life emerges from a network of biomolecules and chemical reactions catalyzed by enzymes. As enzyme abnormalities are often connected to various diseases, a chemical catalyst promoting physiologically important intracellular reactions...
7.
Umeda H, Sawazaki T, Furuta M, Suzuki T, Kawashima S, Mitsunuma H, et al.
ACS Chem Neurosci
. 2023 Jul;
14(15):2710-2716.
PMID: 37470225
Catalytic photo-oxygenation of tau amyloid is a potential therapeutic approach to tauopathies, including Alzheimer disease (AD). However, tau is a complex target containing great molecular size and heterogeneous isoforms/proteoforms. Although...
8.
Oda H, Sato Y, Kawashima S, Fujiwara Y, Palfy M, Wu E, et al.
Biol Open
. 2023 Apr;
12(5).
PMID: 37071022
In the cytoplasm, filamentous actin (F-actin) plays a critical role in cell regulation, including cell migration, stress fiber formation, and cytokinesis. Recent studies have shown that actin filaments that form...
9.
Kawashima S, Kanai M
Methods Mol Biol
. 2022 Sep;
2519:155-161.
PMID: 36066720
Posttranslational modifications (PTMs) of histones, such as lysine acetylation and ubiquitination, regulate chromatin structure and gene expression. In living organisms, histone PTMs are catalyzed by histone-modifying enzymes. Here, we describe...
10.
Zhang J, Li Q, Kawashima S, Nasr M, Xue F, Zhao R
Pathogens
. 2022 Jul;
11(7).
PMID: 35890048
Fission yeast can be used as a cell-based system for high-throughput drug screening. However, higher drug concentrations are often needed to achieve the same effect as in mammalian cells. Our...