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Shichina Kannambath

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Articles 16
Citations 317
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Recent Articles
1.
Doyle R, Kannambath S, Pittman A, Goliath R, Kumar V, Meintjes G, et al.
J Infect Dis . 2024 Aug; 231(1):e254-e262. PMID: 39158391
Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans are opportunistic fungal pathogens associated with infections in immunocompromised hosts. Cryptococcal meningitis (CM) is the leading fungal cause of human immunodeficiency virus-related deaths...
2.
Vantourout P, Eum J, Conde Poole M, Hayday T, Laing A, Hussain K, et al.
Sci Adv . 2023 Dec; 9(49):eadj6174. PMID: 38055824
Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly mediated by complementarity-determining region 3 motifs...
3.
Dart R, Zlatareva I, Vantourout P, Theodoridis E, Amar A, Kannambath S, et al.
Science . 2023 Sep; 381(6663):eadh0301. PMID: 37708268
Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T...
4.
Crescioli S, Correa I, Ng J, Willsmore Z, Laddach R, Chenoweth A, et al.
Nat Commun . 2023 Jun; 14(1):3378. PMID: 37291228
B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail....
5.
Apollonio B, Spada F, Petrov N, Cozzetto D, Papazoglou D, Jarvis P, et al.
J Clin Invest . 2023 May; 133(13). PMID: 37219943
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within the tumor microenvironment (TME). However, the...
6.
Povoleri G, Durham L, Gray E, Lalnunhlimi S, Kannambath S, Pitcher M, et al.
Cell Rep . 2023 May; 42(5):112514. PMID: 37195862
CD69+CD103+ tissue-resident memory T (T) cells are important drivers of inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high-dimensional profiling to T cells from the joints of...
7.
Caetano A, Redhead Y, Karim F, Dhami P, Kannambath S, Nuamah R, et al.
Elife . 2023 Jan; 12. PMID: 36648332
The interplay among different cells in a tissue is essential for maintaining homeostasis. Although disease states have been traditionally attributed to individual cell types, increasing evidence and new therapeutic options...
8.
Olaniru O, Kadolsky U, Kannambath S, Vaikkinen H, Fung K, Dhami P, et al.
Cell Metab . 2022 Dec; 35(1):184-199.e5. PMID: 36513063
Current differentiation protocols have not been successful in reproducibly generating fully functional human beta cells in vitro, partly due to incomplete understanding of human pancreas development. Here, we present detailed...
9.
Kannambath S, Jarvis J, Wake R, Longley N, Loyse A, Matzaraki V, et al.
Open Forum Infect Dis . 2020 Dec; 7(11):ofaa489. PMID: 33269293
Background: is the most common cause of meningitis in human immunodeficiency virus (HIV)-infected Africans. Despite universal exposure, only 5%-10% of patients with HIV/acquired immune deficiency syndrome and profound CD4 T-cell...
10.
Beatson R, Graham R, Grundland Freile F, Cozzetto D, Kannambath S, Pfeifer E, et al.
Commun Biol . 2020 Nov; 3(1):644. PMID: 33149188
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated...