Sheryl A Hyland
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Explore the profile of Sheryl A Hyland including associated specialties, affiliations and a list of published articles.
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11
Citations
44
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Recent Articles
1.
Thompson C, Ali A, Quraishi N, Lu Z, Hammond M, Sinclair P, et al.
ACS Med Chem Lett
. 2014 Jun;
2(6):424-7.
PMID: 24900324
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C...
2.
Lu Z, Chen Y, Napolitano J, Taylor G, Ali A, Hammond M, et al.
Bioorg Med Chem Lett
. 2011 Dec;
22(1):199-203.
PMID: 22142541
SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new...
3.
Smith C, Ali A, Hammond M, Li H, Lu Z, Napolitano J, et al.
J Med Chem
. 2011 Jun;
54(13):4880-95.
PMID: 21682257
The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically,...
4.
Sweis R, Hunt J, Sinclair P, Chen Y, Eveland S, Guo Q, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(9):2597-600.
PMID: 21398121
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Efforts focused on finding suitable replacements for the central piperidine with the aim of reducing hERG...
5.
Sweis R, Hunt J, Kallashi F, Hammond M, Chen Y, Eveland S, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(6):1890-5.
PMID: 21147531
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the...
6.
Kallashi F, Kim D, Kowalchick J, Park Y, Hunt J, Ali A, et al.
Bioorg Med Chem Lett
. 2010 Nov;
21(1):558-61.
PMID: 21094047
We describe structure-activity studies leading to the discovery of 2-arylbenzoxazole 3, the first in a series to raise serum high-density lipoprotein cholesterol levels in transgenic mice. Replacement of the 4-piperidinyloxy...
7.
Lu Z, Napolitano J, Theberge A, Ali A, Hammond M, Tan E, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7469-72.
PMID: 21041082
A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to...
8.
2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety
Hunt J, Gonzalez S, Kallashi F, Hammond M, Pivnichny J, Tong X, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(3):1019-22.
PMID: 20036121
The development of a series of 2-arylbenzoxazole alpha-alkoxyamide and beta-alkoxyamine inhibitors of cholesteryl ester transfer protein (CETP) is described. Highly fluorinated alpha-alkoxyamides proved to be potent inhibitors of CETP in...
9.
Smith C, Ali A, Chen L, Hammond M, Anderson M, Chen Y, et al.
Bioorg Med Chem Lett
. 2009 Nov;
20(1):346-9.
PMID: 19914065
A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5-...
10.
Eveland S, Milot D, Guo Q, Chen Y, Hyland S, Peterson L, et al.
Anal Biochem
. 2007 Jul;
368(2):239-49.
PMID: 17601482
Cholesteryl ester transfer protein (CETP) is a serum component responsible for both cholesteryl ester and triglyceride trafficking between high-density lipoprotein (HDL) and the apolipoprotein B (apoB)-containing very low-density lipoprotein (VLDL)...