Sherin I Hashem
Overview
Explore the profile of Sherin I Hashem including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
225
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0
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Recent Articles
1.
Manso A, Hashem S, Nelson B, Gault E, Soto-Hermida A, Villarruel E, et al.
Sci Transl Med
. 2020 Mar;
12(535).
PMID: 32188720
Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy associated with multiorgan dysfunction, including the heart, skeletal muscle, and liver. There are no specific treatments, and most male patients...
2.
Hashem S, Murphy A, Divakaruni A, Klos M, Nelson B, Gault E, et al.
J Mol Cell Cardiol
. 2017 May;
108:86-94.
PMID: 28526246
Rationale: Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved, ubiquitous protein that is critical for autophagic flux. Loss of function mutations in the LAMP-2 gene cause Danon disease,...
3.
Panopoulos A, DAntonio M, Benaglio P, Williams R, Hashem S, Schuldt B, et al.
Stem Cell Reports
. 2017 Apr;
8(4):1086-1100.
PMID: 28410642
Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a...
4.
Nelson B, Hashem S, Adler E
Curr Cardiol Rep
. 2017 Mar;
19(3):26.
PMID: 28251514
Purpose Of Review: The aim of this study is to review the published human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) models of cardiac storage disorders and to evaluate the limitations and...
5.
Hashem S, Perry C, Bauer M, Han S, Clegg S, Ouyang K, et al.
Stem Cells
. 2015 Apr;
33(7):2343-50.
PMID: 25826782
Danon disease is a familial cardiomyopathy associated with impaired autophagy due to mutations in the gene encoding lysosomal-associated membrane protein type 2 (LAMP-2). Emerging evidence has highlighted the importance of...
6.
Hashem S, Claycomb W
Mol Cell Biochem
. 2013 Jul;
383(1-2):161-71.
PMID: 23877224
Dysfunction of the cardiac pacemaker tissues due to genetic defects, acquired diseases, or aging results in arrhythmias. When arrhythmias occur, artificial pacemaker implants are used for treatment. However, the numerous...
7.
Hashem S, Lam M, Mihardja S, White S, Lee R, Claycomb W
Stem Cells Dev
. 2013 Jun;
22(21):2915-26.
PMID: 23767866
The pacemaker tissues of the heart are a complex set of specialized cells that initiate the rhythmic heartbeat. The sinoatrial node (SAN) serves as the primary pacemaker, whereas the atrioventricular...
8.
Lam M, Hashem S, Claycomb W
Mol Cell Biochem
. 2010 Dec;
349(1-2):69-76.
PMID: 21127947
The adult mammalian heart is known to contain a population of cardiac progenitor cells. It has not been unambiguously determined, however, whether these cells form as part of the developmental...