Shepherd H Schurman
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Explore the profile of Shepherd H Schurman including associated specialties, affiliations and a list of published articles.
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1491
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Recent Articles
1.
Singh A, Schurman S, Bektas A, Kaileh M, Roy R, Wilson 3rd D, et al.
Cold Spring Harb Perspect Med
. 2023 Dec;
14(6).
PMID: 38052484
Aging can be conceptualized as the progressive disequilibrium between stochastic damage accumulation and resilience mechanisms that continuously repair that damage, which eventually cause the development of chronic disease, frailty, and...
2.
Fecho K, Bizon C, Issabekova T, Moxon S, Thessen A, Abdollahi S, et al.
J Clin Transl Sci
. 2023 Oct;
7(1):e214.
PMID: 37900350
Knowledge graphs have become a common approach for knowledge representation. Yet, the application of graph methodology is elusive due to the sheer number and complexity of knowledge sources. In addition,...
3.
Ajayi T, Rai P, Shi M, Gabor K, Karmaus P, Meacham J, et al.
Sci Rep
. 2023 Aug;
13(1):12911.
PMID: 37558924
Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (-4299T>C), a single...
4.
Ayala-Ramirez M, MacNell N, McNamee L, McGrath J, Akhtari F, Curry M, et al.
Environ Int
. 2022 Dec;
171:107687.
PMID: 36527873
Background: Concentrated animal feeding operations (CAFOs) are a source of environmental pollution and have been associated with a variety of health outcomes. Immune-mediated diseases (IMD) are characterized by dysregulation of...
5.
Lowe M, Akhtari F, Potter T, Fargo D, Schmitt C, Schurman S, et al.
J Expo Sci Environ Epidemiol
. 2022 Dec;
33(3):474-481.
PMID: 36460922
Background: Autoimmune (AI) diseases appear to be a product of genetic predisposition and environmental triggers. Disruption of the skin barrier causes exacerbation of psoriasis/eczema. Oxidative stress is a mechanistic pathway...
6.
Akhtari F, Lloyd D, Burkholder A, Tong X, House J, Lee E, et al.
Diabetes Care
. 2022 Nov;
46(5):929-937.
PMID: 36383734
Objective: Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting...
7.
Lee E, Akhtari F, House J, Simpson Jr R, Schmitt C, Fargo D, et al.
Environ Res
. 2022 May;
212(Pt D):113463.
PMID: 35605674
While multiple factors are associated with cardiovascular disease (CVD), many environmental exposures that may contribute to CVD have not been examined. To understand environmental effects on cardiovascular health, we performed...
8.
Li H, Bradbury J, Edin M, Graves J, Gruzdev A, Cheng J, et al.
J Clin Invest
. 2021 Sep;
131(22).
PMID: 34591792
Epoxyeicosatrienoic acids (EETs) have potent antiinflammatory properties. Hydrolysis of EETs by soluble epoxide hydrolase/ epoxide hydrolase 2 (sEH/EPHX2) to less active diols attenuates their antiinflammatory effects. Macrophage activation is critical...
9.
Schupmann W, Miner S, Sullivan H, Glover J, Hall J, Schurman S, et al.
Genet Med
. 2021 Jul;
23(12):2281-2288.
PMID: 34326490
Purpose: Proposals to return medically actionable secondary genetic findings (SFs) in the clinical and research settings have generated controversy regarding whether to solicit individuals' preferences about their "right not to...
10.
Saini N, Giacobone C, Klimczak L, Papas B, Burkholder A, Li J, et al.
PLoS Genet
. 2021 Jan;
17(1):e1009302.
PMID: 33444353
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also...