Shen Gu
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Explore the profile of Shen Gu including associated specialties, affiliations and a list of published articles.
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70
Citations
1462
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Recent Articles
1.
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT
Yan R, Fan C, Gu S, Wang T, Yin Z, Chen X
Protein Cell
. 2025 Mar;
PMID: 40083145
Identification of disease-specific cell subtypes (DSCSs) has profound implications for understanding disease mechanisms, preoperative diagnosis, and precision therapy. However, achieving unified annotation of DSCSs in heterogeneous single-cell datasets remains a...
2.
Tam H, Liu J, Yiu T, Leung A, Li C, Gu S, et al.
Cell Biosci
. 2025 Jan;
15(1):10.
PMID: 39863890
Background: Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from...
3.
Zhou Z, Pan Y, Zhou S, Wang S, Zhang D, Cao Y, et al.
Front Cell Dev Biol
. 2023 Nov;
11:1209320.
PMID: 38020907
Currently, the mechanism(s) underlying corticogenesis is still under characterization. We curated the most comprehensive single-cell RNA-seq (scRNA-seq) datasets from mouse and human fetal cortexes for data analysis and confirmed the...
4.
Chai Y, Lee S, Shillington A, Du X, Fok C, Yeung K, et al.
IBRO Neurosci Rep
. 2023 Oct;
15:218-224.
PMID: 37822516
Rett Syndrome (RTT) is a neurodevelopmental disorder caused by pathogenic variants in the gene. While the majority of RTT-causing variants are clustered in the methyl-CpG binding domain and NCoR/SMRT interaction...
5.
Calame D, Guo T, Wang C, Garrett L, Jolly A, Dawood M, et al.
Am J Hum Genet
. 2023 Jul;
110(8):1394-1413.
PMID: 37467750
DExD/H-box RNA helicases (DDX/DHX) are encoded by a large paralogous gene family; in a subset of these human helicase genes, pathogenic variation causes neurodevelopmental disorder (NDD) traits and cancer. DHX9...
6.
Zhao Y, Gu S, Li L, Zhao R, Xie S, Zhang J, et al.
Neuro Oncol
. 2023 Jun;
25(12):2207-2220.
PMID: 37379245
Background: Brain metastasis (BM) are a devastating consequence of lung cancer. This study was aimed to screen risk factors for predicting BM. Methods: Using an in vivo BM preclinical model,...
7.
Gu S, Xu W, Wang L, Zhao H
Biochem Biophys Res Commun
. 2023 Jun;
671:350-356.
PMID: 37329658
Gallbladder carcinoma (GBC) is the most prevalent cancer of the bile tract, with unexpected GBC accounting for almost half of all GBC cases in some tertiary medical centers. Although the...
8.
Ho N, Chen X, Lei Y, Gu S
Zool Res
. 2023 May;
44(3):650-662.
PMID: 37161652
Hereditary spastic paraplegia (HSP) is a group of genetic motor neuron diseases resulting from length-dependent axonal degeneration of the corticospinal upper motor neurons. Due to the advancement of next-generation sequencing,...
9.
Leung A, Yiu T, Liu L, Tam H, Gu S, Tu J, et al.
Cell Biosci
. 2022 Dec;
12(1):212.
PMID: 36587229
Background: Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the...
10.
Zhu W, Wang C, Mullapudi N, Cao Y, Li L, Lo I, et al.
NPJ Genom Med
. 2022 Dec;
7(1):72.
PMID: 36535936
Single gene disorders are individually rare but collectively common leading causes of neonatal and pediatric morbidity and mortality. Both parents or the mothers of affected individuals with autosomal recessive or...