Shelly Sorrells
Overview
Explore the profile of Shelly Sorrells including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
209
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0
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Recent Articles
1.
Sorrells S, McKinnon K, McBratney A, Sumey C
NPJ Genom Med
. 2021 Feb;
6(1):17.
PMID: 33619265
BRCA-mutant cancers often develop therapeutic resistance through several mechanisms. Here, we report a case of pathogenic germline BRCA2-driven breast cancer monitored for disease progression and acquired resistance using longitudinal multi-tissue...
2.
Beaubier N, Tell R, Lau D, Parsons J, Bush S, Perera J, et al.
Oncotarget
. 2019 May;
10(24):2384-2396.
PMID: 31040929
We developed and clinically validated a hybrid capture next generation sequencing assay to detect somatic alterations and microsatellite instability in solid tumors and hematologic malignancies. This targeted oncology assay utilizes...
3.
Sorrells S, Nik S, Casey M, Cameron R, Truong H, Toruno C, et al.
Dis Model Mech
. 2018 Feb;
11(2).
PMID: 29419415
RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one...
4.
Patel J, Schumacher J, Frizzell K, Sorrells S, Shen W, Clayton A, et al.
Leuk Res
. 2017 Feb;
56:7-12.
PMID: 28152414
NPM1 insertion mutations represent a common recurrent genetic abnormality in acute myeloid leukemia (AML) patients. The frequency of these mutations varies from approximately 30% overall up to 50% in patients...
5.
Sorrells S, Toruno C, Stewart R, Jette C
J Vis Exp
. 2014 Jan;
(82):e51060.
PMID: 24378359
Whole-mount immunofluorescence to detect activated Caspase 3 (Casp3 assay) is useful to identify cells undergoing either intrinsic or extrinsic apoptosis in zebrafish embryos. The whole-mount analysis provides spatial information in...
6.
Saenz Robles M, Shivalila C, Wano J, Sorrells S, Roos A, Pipas J
J Virol
. 2013 Oct;
87(24):13499-509.
PMID: 24089570
Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regulation and thus has been used to identify cellular components controlling proliferation and homeostasis. We have previously shown...
7.
Sorrells S, Carbonneau S, Harrington E, Chen A, Hast B, Milash B, et al.
PLoS Genet
. 2012 Sep;
8(8):e1002922.
PMID: 22952453
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation...