Sheila K Pirooznia
Overview
Explore the profile of Sheila K Pirooznia including associated specialties, affiliations and a list of published articles.
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9
Citations
220
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Recent Articles
1.
Pirooznia S, Wang H, Panicker N, Kumar M, Neifert S, Dar M, et al.
Sci Adv
. 2022 Apr;
8(13):eabh1824.
PMID: 35363524
Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson's disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation...
2.
Pirooznia S, Rosenthal L, Dawson V, Dawson T
Pharmacol Rev
. 2021 Oct;
73(4):33-97.
PMID: 34663684
Parkinson disease (PD) used to be considered a nongenetic condition. However, the identification of several autosomal dominant and recessive mutations linked to monogenic PD has changed this view. Clinically manifest...
3.
Pirooznia S, Yuan C, Khan M, Karuppagounder S, Wang L, Xiong Y, et al.
Mol Neurodegener
. 2020 Mar;
15(1):17.
PMID: 32138754
Background: Mutations in PINK1 and parkin cause autosomal recessive Parkinson's disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However,...
4.
Pirooznia S, Dawson V, Dawson T
Neuron
. 2014 Mar;
81(5):961-963.
PMID: 24607221
Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and...
5.
Johnson A, Sarthi J, Pirooznia S, Reube W, Elefant F
J Neurosci
. 2013 Apr;
33(17):7535-47.
PMID: 23616558
Axonal transport defects and axonopathy are prominent in early preclinical stages of Alzheimer's disease (AD), often preceding known disease-related pathology by over a year. As epigenetic transcriptional regulatory mechanisms, such...
6.
Pirooznia S, Elefant F
Fly (Austin)
. 2013 Apr;
7(2):99-104.
PMID: 23572111
Sleep disturbances are common in neurodegenerative diseases such as Alzheimer disease (AD). Unfortunately, how AD is mechanistically linked with interference of the body's natural sleep rhythms remains unclear. Our recent...
7.
Pirooznia S, Elefant F
Front Cell Neurosci
. 2013 Apr;
7:30.
PMID: 23543406
Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome...
8.
Pirooznia S, Chiu K, Chan M, Zimmerman J, Elefant F
Genetics
. 2012 Sep;
192(4):1327-45.
PMID: 22982579
Tip60 is a histone acetyltransferase (HAT) enzyme that epigenetically regulates genes enriched for neuronal functions through interaction with the amyloid precursor protein (APP) intracellular domain. However, whether Tip60-mediated epigenetic dysregulation...
9.
Pirooznia S, Sarthi J, Johnson A, Toth M, Chiu K, Koduri S, et al.
PLoS One
. 2012 Aug;
7(7):e41776.
PMID: 22848598
Histone acetylation of chromatin promotes dynamic transcriptional responses in neurons that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 histone acetyltransferase (HAT) activity is involved in...