Shawn D Blackburn
Overview
Explore the profile of Shawn D Blackburn including associated specialties, affiliations and a list of published articles.
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10
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2506
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Recent Articles
1.
Walsh K, Teijaro J, Zuniga E, Welch M, Fremgen D, Blackburn S, et al.
Cell Host Microbe
. 2012 Jun;
11(6):643-53.
PMID: 22704624
TLR7 is an innate signaling receptor that recognizes single-stranded viral RNA and is activated by viruses that cause persistent infections. We show that TLR7 signaling dictates either clearance or establishment...
2.
Angelosanto J, Blackburn S, Crawford A, Wherry E
J Virol
. 2012 May;
86(15):8161-70.
PMID: 22623779
T cell exhaustion and loss of memory potential occur during many chronic viral infections and cancer. We investigated when during chronic viral infection virus-specific CD8 T cells lose the potential...
3.
Crawford A, Angelosanto J, Nadwodny K, Blackburn S, Wherry E
PLoS Pathog
. 2011 Aug;
7(7):e1002098.
PMID: 21814510
RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute...
4.
Blackburn S, Crawford A, Shin H, Polley A, Freeman G, Wherry E
J Virol
. 2009 Dec;
84(4):2078-89.
PMID: 19955307
The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion during chronic viral infections in animal models, as well as in humans, and blockade of this pathway can revive...
5.
Shin H, Blackburn S, Intlekofer A, Kao C, Angelosanto J, Reiner S, et al.
Immunity
. 2009 Aug;
31(2):309-20.
PMID: 19664943
T cell exhaustion is common during chronic infections and can prevent optimal immunity. Although recent studies have demonstrated the importance of inhibitory receptors and other pathways in T cell exhaustion,...
6.
Blackburn S, Shin H, Nicholas Haining W, Zou T, Workman C, Polley A, et al.
Nat Immunol
. 2008 Dec;
10(1):29-37.
PMID: 19043418
T cell exhaustion often occurs during chronic infection and prevents optimal viral control. The molecular pathways involved in T cell exhaustion remain poorly understood. Here we show that exhausted CD8+...
7.
Blackburn S, Shin H, Freeman G, Wherry E
Proc Natl Acad Sci U S A
. 2008 Sep;
105(39):15016-21.
PMID: 18809920
Programmed death-1 (PD-1) regulates T cell exhaustion during chronic infections. Blocking the PD-1:PD-ligand (PD-L) pathway reinvigorates exhausted CD8 T cells. Exactly how blocking PD-1:PD-L interactions improves T cell immunity, however,...
8.
Shin H, Blackburn S, Blattman J, Wherry E
J Exp Med
. 2007 Apr;
204(4):941-9.
PMID: 17420267
Efficient maintenance of memory CD8 T cells is central to long-term protective immunity. IL-7- and IL-15-driven homeostatic proliferation is essential for long-term memory CD8 T cell persistence after acute infections....
9.
Blackburn S, Wherry E
Trends Microbiol
. 2007 Mar;
15(4):143-6.
PMID: 17336072
Viral infections can have one of two outcomes: control of viral replication and acute infection or viral persistence and chronic infection. It is clear that both pathogen and host characteristics...
10.
Johnson F, Fenn L, Owens T, Faucheux L, Blackburn S
J Gen Virol
. 2004 Jul;
85(Pt 8):2199-2207.
PMID: 15269359
Although it has previously been shown that bovine parvovirus (BPV) attaches to the sialated glycoprotein glycophorin A on erythrocytes, the nature of virus-binding moieties on mammalian nucleated cells is less...