Shauna McElwain
Overview
Explore the profile of Shauna McElwain including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
493
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Recent Articles
1.
Le A, Cho J, Miller M, McElwain S, Golgotiu K, Broide D
J Immunol
. 2007 May;
178(11):7310-6.
PMID: 17513781
Intracellular signaling pathways that converge on Smad 3 are used by both TGF-beta and activin A, key cytokines implicated in the process of fibrogenesis. To determine the role of Smad...
2.
Min M, Song D, Miller M, Cho J, McElwain S, Ferguson P, et al.
J Immunol
. 2007 Apr;
178(8):5321-8.
PMID: 17404317
Environmental tobacco smoke (ETS) can increase asthma symptoms and the frequency of asthma attacks. However, the contribution of ETS to airway remodeling in asthma is at present unknown. In this...
3.
Lim D, Cho J, Miller M, McElwain K, McElwain S, Broide D
Am J Physiol Lung Cell Mol Physiol
. 2006 Jul;
291(2):L265-71.
PMID: 16825657
Matrix metalloproteinases (MMPs) are a family of extracellular proteases that are responsible for the degradation of the extracellular matrix during tissue remodeling. We have used a mouse model of allergen-induced...
4.
Cho J, Miller M, McElwain K, McElwain S, Shim J, Raz E, et al.
J Allergy Clin Immunol
. 2006 Mar;
117(3):618-25.
PMID: 16522462
Background: Matrix metalloproteinase 9 (MMP-9) and its tissue inhibitor of metalloproteinase 1 (TIMP-1) are hypothesized to play a role in the pathogenesis of airway remodeling in asthma. Objective: We have...
5.
Lee S, Cho J, Miller M, McElwain K, McElwain S, Sriramarao P, et al.
J Allergy Clin Immunol
. 2006 Mar;
117(3):597-603.
PMID: 16522459
Background: Airway remodeling in asthma is associated with angiogenesis. Objective: We have examined whether immunostimulatory sequences of DNA (ISSs) inhibit allergen-induced airway angiogenesis and expression of angiogenic cytokines in a...
6.
Miller M, Cho J, McElwain K, McElwain S, Shim J, Manni M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2005 Dec;
290(1):L162-9.
PMID: 16344333
At present there are conflicting results from studies investigating the role of corticosteroids in inhibiting airway remodeling in asthma. We have used a mouse model to determine whether administration of...
7.
Broide D, Lawrence T, Doherty T, Cho J, Miller M, McElwain K, et al.
Proc Natl Acad Sci U S A
. 2005 Dec;
102(49):17723-8.
PMID: 16317067
In response to inflammation or injury, airway epithelial cells express inducible genes that may contribute to allergen-induced airway remodeling. To determine the contribution of epithelial cell NF-kappaB activation to the...
8.
Cho J, Miller M, McElwain K, McElwain S, Broide D
J Allergy Clin Immunol
. 2005 Nov;
116(5):1116-22.
PMID: 16275385
Background: Allergen avoidance and anti-inflammatory therapy are standard therapeutic approaches guidelines advocate to control asthma symptoms. Currently, it is not known whether such strategies reduce airway remodeling. Objective: We have...
9.
Youn C, Miller M, Baek K, Han J, Nayar J, Lee S, et al.
J Immunol
. 2004 Dec;
173(12):7556-64.
PMID: 15585883
To determine whether immunostimulatory sequences of DNA (ISS) can reverse established airway remodeling, mice that had developed airway remodeling following 3 mo of repetitive OVA challenges, were treated with ISS...
10.
Cho J, Miller M, Baek K, Han J, Nayar J, Lee S, et al.
J Clin Invest
. 2004 Feb;
113(4):551-60.
PMID: 14966564
To determine the role of IL-5 in airway remodeling, IL-5-deficient and WT mice were sensitized to OVA and challenged by repetitive administration of OVA for 3 months. IL-5-deficient mice had...