Sharon Tran
Overview
Explore the profile of Sharon Tran including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
250
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Recent Articles
1.
Atkin-Smith G, Santavanond J, Light A, Rimes J, Samson A, Er J, et al.
Nat Commun
. 2024 Oct;
15(1):8802.
PMID: 39438460
Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and...
2.
Tran S, Juliani J, Harris T, Evangelista M, Ratcliffe J, Ellis S, et al.
Commun Biol
. 2024 Feb;
7(1):209.
PMID: 38378743
Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intestinal...
3.
Tran S, Juliani J, Fairlie W, Lee E
Biochem Soc Trans
. 2023 Apr;
51(2):811-826.
PMID: 37052218
Landmark genome-wide association studies (GWAS) identified that mutations in autophagy genes correlated with inflammatory bowel disease (IBD), a heterogenous disease characterised by prolonged inflammation of the gastrointestinal tract, that can...
4.
Jenkins L, Luk I, Fairlie W, Lee E, Palmieri M, Schoffer K, et al.
Mol Cancer Ther
. 2022 Nov;
22(1):52-62.
PMID: 36343387
The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they primarily induce cytostatic effects in colorectal cancer cells....
5.
Montano E, Nideffer J, Brumage L, Erb M, Busch J, Fernandez L, et al.
PLoS One
. 2022 Jan;
17(1):e0262354.
PMID: 35061755
The threat to public health posed by drug-resistant bacteria is rapidly increasing, as some of healthcare's most potent antibiotics are becoming obsolete. Approximately two-thirds of the world's antibiotics are derived...
6.
Tran S, Fairlie W, Lee E
Cells
. 2021 Jul;
10(6).
PMID: 34204202
BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate...
7.
Young N, Harris T, Evangelista M, Tran S, Wouters M, Soares da Costa T, et al.
Commun Biol
. 2020 Aug;
3(1):478.
PMID: 32859965
Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with...
8.
Fairlie W, Tran S, Lee E
Int Rev Cell Mol Biol
. 2020 Apr;
352:115-158.
PMID: 32334814
The fate of a cell is determined by multiple signaling pathways in response to a range of stimuli. Probably the most prominent cell death mechanism is apoptosis which can be...
9.
Lee E, Harris T, Tran S, Evangelista M, Arulananda S, John T, et al.
Cell Death Dis
. 2019 Apr;
10(5):342.
PMID: 31019203
Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint inhibitors, many patients do...
10.
Lee E, Smith N, Soares da Costa T, Meftahi N, Yao S, Harris T, et al.
Autophagy
. 2019 Jan;
15(5):785-795.
PMID: 30626284
BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain...