Sharon Chee
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Explore the profile of Sharon Chee including associated specialties, affiliations and a list of published articles.
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10
Citations
74
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Recent Articles
1.
Levitskaya Z, Ser Z, Koh H, Mei W, Chee S, Sobota R, et al.
RSC Chem Biol
. 2024 Apr;
5(4):372-385.
PMID: 38576719
Phenotypic screening is a valuable tool to both understand and engineer complex biological systems. We demonstrate the functionality of this approach in the development of cell-free protein synthesis (CFPS) technology....
2.
Sana B, Ding K, Siau J, Pasula R, Chee S, Kharel S, et al.
Biotechnol Bioeng
. 2023 Aug;
120(11):3200-3209.
PMID: 37555384
Polyethylene terephthalate (PET) hydrolase enzymes show promise for enzymatic PET degradation and green recycling of single-use PET vessels representing a major source of global pollution. Their full potential can be...
3.
Siau J, Nonis S, Chee S, Koh L, Ferrer F, Brown C, et al.
Nucleic Acids Res
. 2020 Oct;
48(22):e128.
PMID: 33104786
Directed evolution methodologies benefit from read-outs quantitatively linking genotype to phenotype. We therefore devised a method that couples protein-peptide interactions to the dynamic read-out provided by an engineered DNA polymerase....
4.
Kannan S, Aronica P, Ng S, Gek Lian D, Frosi Y, Chee S, et al.
Chem Sci
. 2020 Sep;
11(21):5577-5591.
PMID: 32874502
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein-protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these...
5.
Raghavan S, Chee S, Li J, Poschmann J, Nagarajan N, Jia Wei S, et al.
Microb Cell Fact
. 2019 Aug;
18(1):139.
PMID: 31426802
Background: Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing "green" acrylic...
6.
Jia Wei S, Chee S, Yurlova L, Lane D, Verma C, Brown C, et al.
Oncotarget
. 2016 Apr;
7(22):32232-46.
PMID: 27057630
Cancer drugs often fail due to the emergence of clinical resistance. This can manifest through mutations in target proteins that selectively exclude drug binding whilst retaining aberrant function. A priori...
7.
Vijaya Chandra S, Makhija H, Peter S, Wai C, Li J, Zhu J, et al.
Nucleic Acids Res
. 2015 Dec;
44(6):e55.
PMID: 26673710
Genome engineering of human cells plays an important role in biotechnology and molecular medicine. In particular, insertions of functional multi-transgene cassettes into suitable endogenous sequences will lead to novel applications....
8.
Siau J, Chee S, Makhija H, Wai C, Vijaya Chandra S, Peter S, et al.
Protein Eng Des Sel
. 2015 Mar;
28(7):211-20.
PMID: 25787692
Advances in genome engineering are attendant on the development of novel enzyme variants with programed substrate specificities and improved activity. We have devised a novel selection method, wherein the activity...
9.
Jia Wei S, Joseph T, Chee S, Li L, Yurlova L, Zolghadr K, et al.
PLoS One
. 2013 Nov;
8(11):e81068.
PMID: 24278380
Pharmacological modulation of p53 activity is an attractive therapeutic strategy in cancers with wild-type p53. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2, a key negative...
10.
Nirantar S, Yeo K, Chee S, Lane D, Ghadessy F
Biosens Bioelectron
. 2013 Apr;
47:421-8.
PMID: 23612064
Numerous peptide ligands including protease recognition sequences, peptides mediating protein-protein interactions, peptide epitopes of antibodies and mimotopes are available which bind molecules of interest. However, there is currently no facile...