David Lane
Overview
Explore the profile of David Lane including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
1508
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Recent Articles
1.
Spiegelberg D, Hwang L, Pua K, Kumar S, Koh X, Koh X, et al.
Sci Rep
. 2025 Jan;
15(1):1000.
PMID: 39762369
About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53 (p53 in mice) is a hotspot mutation in various...
2.
Philippe G, Huang Y, Mittermeier A, Brown C, Kaas Q, Ramlan S, et al.
J Med Chem
. 2024 Jan;
67(2):1197-1208.
PMID: 38174919
Peptides are promising drug modalities that can modulate protein-protein interactions, but their application is hampered by their limited ability to reach intracellular targets. Here, we improved the cytosolic delivery of...
3.
Maziero M, Lane D, Polard P, Berge M
PLoS Genet
. 2023 Sep;
19(9):e1010946.
PMID: 37699047
Streptococcus pneumoniae (the pneumococcus) is well known for its ability to develop competence for natural DNA transformation. Competence development is regulated by an autocatalytic loop driven by variations in the...
4.
Xue Y, Luis B, Dress R, Murad K, Ginhoux F, Barker N, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(13):e2219978120.
PMID: 36940336
We have previously shown that proteasome inhibitor bortezomib stabilizes p53 in stem and progenitor cells within gastrointestinal tissues. Here, we characterize the effect of bortezomib treatment on primary and secondary...
5.
Kent D, Marquez-Grant N, Lane D
Sci Justice
. 2022 Nov;
62(5):582-593.
PMID: 36336451
The need to forensically search soil for small artefacts at a burial site or traces of evidence in a deposition site is a common task shared by investigators and forensic...
6.
Goh C, Wong J, El Farran C, Tan B, Coffill C, Loh Y, et al.
G3 (Bethesda)
. 2022 Feb;
12(3).
PMID: 35169844
No abstract available.
7.
Gulliver W, Gulliver S, Power R, Penney M, Lane D
Dermatology
. 2021 Oct;
238(3):527-533.
PMID: 34610598
Background: The incidence of cutaneous malignant melanoma continues to increase worldwide and in Canada. It is unclear whether the increase in incidence and clinical characteristic trends of cutaneous malignant melanoma...
8.
Lane D, Schiller T
Open Vet J
. 2021 Feb;
10(4):457-464.
PMID: 33614442
Background: Bicipital tendinitis and/or tendinopathy is a common cause of forelimb lameness in dogs, particularly in larger and more active patients. Although conservative treatment aimed at resolving discomfort and preserving...
9.
Goh C, Wong J, El Farran C, Tan B, Coffill C, Loh Y, et al.
G3 (Bethesda)
. 2021 Feb;
11(2).
PMID: 33604667
Vemurafenib is a BRAF kinase inhibitor (BRAFi) that is used to treat melanoma patients harboring the constitutively active BRAF-V600E mutation. However, after a few months of treatment patients often develop...
10.
Magyar B, Tsiogkas N, Brito B, Patel M, Lane D, Wang S
Front Robot AI
. 2021 Jan;
6:105.
PMID: 33501120
Learning from Demonstration (LfD) is a family of methods used to teach robots specific tasks. It is used to assist them with the increasing difficulty of performing manipulation tasks in...