Sharon C Lehec
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Explore the profile of Sharon C Lehec including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
274
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Recent Articles
1.
Dhawan A, Chaijitraruch N, Fitzpatrick E, Bansal S, Filippi C, Lehec S, et al.
J Hepatol
. 2019 Dec;
72(5):877-884.
PMID: 31843649
Background & Aims: Liver transplantation (LT) is the most effective treatment for patients with acute liver failure (ALF), but is limited by surgical risks and the need for life-long immunosuppression....
2.
Jitraruch S, Dhawan A, Hughes R, Filippi C, Lehec S, Glover L, et al.
Cell Transplant
. 2017 Sep;
26(8):1341-1354.
PMID: 28901189
Intraperitoneal transplantation of hepatocyte microbeads is an attractive option for the management of acute liver failure. Encapsulation of hepatocytes in alginate microbeads supports their function and prevents immune attack of...
3.
Jitraruch S, Dhawan A, Hughes R, Filippi C, Soong D, Philippeos C, et al.
PLoS One
. 2014 Dec;
9(12):e113609.
PMID: 25438038
Background And Aim: Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive option for the management of acute liver failure (ALF) providing short-term support to allow native liver regeneration. The...
4.
Fitzpatrick E, Wu Y, Dhadda P, Hughes R, Mitry R, Qin H, et al.
Cell Transplant
. 2013 Oct;
24(1):73-83.
PMID: 24143888
Hepatocyte transplantation is becoming an accepted therapy for acute liver failure, either as a bridge to liver regeneration or to organ transplantation. Hepatocytes provide liver function in place of the...
5.
Ex vivo magnetic resonance imaging of transplanted hepatocytes in a rat model of acute liver failure
Puppi J, Modo M, Dhawan A, Lehec S, Mitry R, Hughes R
Cell Transplant
. 2013 Feb;
23(3):329-43.
PMID: 23394812
Hepatocyte transplantation is being evaluated as an alternative to liver transplantation. However, the fate of hepatocytes after transplantation is not well defined. The aims of the study were to improve...
6.
Ho C, Dhawan A, Hughes R, Lehec S, Puppi J, Philippeos C, et al.
Asian J Surg
. 2012 Jun;
35(1):9-15.
PMID: 22726558
Background/objective: Hepatocyte transplantation is a promising alternative to liver transplantation in children with liver metabolic disorders and acute liver failure. Currently, it is difficult to assess rapidly hepatocyte function before...
7.
Mitry R, Lehec S, Hughes R
Methods Mol Biol
. 2010 Jul;
640:107-13.
PMID: 20645048
Cryopreservation of hepatocytes is important for use both in research and for clinical application in hepatocyte transplantation. Cryopreservation causes damage to hepatocytes with the result that cell viability and function...
8.
Sagias F, Mitry R, Hughes R, Lehec S, Patel A, Rela M, et al.
Cell Transplant
. 2010 Jul;
19(11):1487-92.
PMID: 20587150
Hepatocyte transplantation is dependent on the availability of good quality human hepatocytes isolated from donor liver tissue. Hepatocytes obtained from livers rejected for transplantation on the grounds of steatosis are...
9.
Terry C, Dhawan A, Mitry R, Lehec S, Hughes R
Liver Transpl
. 2010 Jan;
16(2):229-37.
PMID: 20104500
Cryopreservation of human hepatocytes is important for their use in hepatocyte transplantation. On thawing, cryopreserved hepatocytes often have reduced viability and metabolic function in comparison with fresh cells. The aim...
10.
Lehec S, Hughes R, Mitry R, Graver M, Verma A, Wade J, et al.
Cell Transplant
. 2009 Jun;
18(8):941-7.
PMID: 19523347
Hepatocyte transplantation is being used in patients with liver-based metabolic disorders and acute liver failure. Hepatocytes are isolated from unused donor liver tissue under GMP conditions. Cells must be free...