Sharad Mistry

Two monoterpenoid lactones, loliolide () and -loliolide (), were isolated from the crude dichloromethane extract of a microalga, sp.). The structures of loliolide () and -loliolide () were elucidated by...

Five undescribed pentaketide derivatives, ()-6,8-dihydroxy-4,5-dimethyl-3-methylidene-3,4-dihydro-1-2-benzopyran-1-one (), [(3,4)-3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-3,4-dihydro-1-isochromen-3-yl]methyl acetate (), ()-5, 7-dimethoxy-3-((-(1-hydroxyethyl)-3,4-dimethylisobenzofuran-1(3)-one (), ()-7-hydroxy-3-(()-1-hydroxyethyl)-5-methoxy-3,4-dimethylisobenzofuran 1(3)-one (), and a -hydroxyphenyl-2-pyridone derivative, avellaneanone (), were isolated together with the previously reported ()-3-acetyl-7-hydroxy-5-methoxy-3,4-dimethylisobenzofuran-1(3)-one (),...

An undescribed hybrid phenalenone dimer, talaropinophilone (), an unreported azaphilone, 7--pinazaphilone B (), an unreported phthalide dimer, talaropinophilide (), and an undescribed 9,15-dihydroxy-ergosta-4,6,8 (14)-tetraen-3-one () were isolated together with the...

An unreported isocoumarin, (,4)-4-hydroxy-6-methoxymellein (), an undescribed propylpyridinium anthraquinone (), and an unreported C-glucosyl resorcinol derivative, acetyl carnemycin E (), were isolated, together with eight previously reported metabolites including -hydroxybenzaldehyde...

Previously unreported anthraquinone, acetylpenipurdin A (), biphenyl ether, neospinosic acid (), dibenzodioxepinone, and spinolactone () were isolated, together with ()-6-hydroxymellein (), penipurdin A (), acetylquestinol (), tenellic acid C (),...

Four undescribed prenylated phenylbutyrolactones, aspulvinones R, S, T and U, were isolated together with the previously reported aspulvinones A, B', H and 4-hydroxy-3,5-bis(3-methylbut-2-en-1-yl)benzaldehyde, from cultures of the marine sponge-derived fungus...

Two undescribed viomellein derivatives, xanthoelegansin and spiroxanthoelegansin, were isolated together with clavatol, sitosteanone, vioxanthin, xanthomegnin, viomellein, rubrosulphin, rubrosulphin diacetate, viopurpurin , ochratoxin A, ochratoxin A methyl ester, ochratoxin B and...

Previously unreported meroterpene, acremine S (), and benzopyran derivative, acremine T (), were isolated, together with lumichrome (), ergosterol () and ergosterol 5,8-endoperoxide, from cultures of the marine sponge-associated fungus...

Paget's disease of bone (PDB) is a chronic skeletal disorder that can affect one or several bones in individuals older than 55 y of age. PDB-like changes have been reported...

Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By...