Shaopeng Chi
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Explore the profile of Shaopeng Chi including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
763
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Recent Articles
1.
Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions
Chi S, Cui Y, Wang H, Jiang J, Zhang T, Sun S, et al.
Neuron
. 2022 Aug;
110(18):2984-2999.e8.
PMID: 35963237
Adult brain activities are generally believed to be dominated by chemical and electrical transduction mechanisms. However, the importance of mechanotransduction mediated by mechano-gated ion channels in brain functions is less...
2.
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, et al.
Elife
. 2019 Jul;
8.
PMID: 31290742
Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone...
3.
Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, et al.
Nature
. 2018 Sep;
563(7730):E19.
PMID: 30202093
In Extended Data Fig. 9a of this Article, the bottom micrographs of mPiezo1-ΔL3-4-IRES-GFP and mPiezo1-ΔL7-8-IRES-GFP (labelled 'permeabilized') are inadvertently the same images. The corrected figure panels are shown in the...
4.
Wang Y, Chi S, Guo H, Li G, Wang L, Zhao Q, et al.
Nat Commun
. 2018 Apr;
9(1):1300.
PMID: 29610524
Piezo1 represents a prototype of eukaryotic mechanotransduction channels. The full-length 2547-residue mouse Piezo1 possesses a unique 38-transmembrane-helix (TM) topology and is organized into a three-bladed, propeller-shaped architecture, comprising a central...
5.
Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, et al.
Nature
. 2018 Feb;
554(7693):487-492.
PMID: 29469092
The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here we determine the three-bladed, propeller-like electron cryo-microscopy structure of mouse Piezo1 and...
6.
Zhang T, Chi S, Jiang F, Zhao Q, Xiao B
Nat Commun
. 2017 Nov;
8(1):1797.
PMID: 29176668
Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trimer comprising a central pore-module...
7.
Zhao Q, Wu K, Chi S, Geng J, Xiao B
Neuron
. 2017 Apr;
94(2):274-277.
PMID: 28426963
Piezo1 represents a prototype of the mammalian mechanosensitive cation channel, but its molecular mechanism remains elusive. In a recent study, we showed that C-terminal region, which contains the last two...
8.
Zhao Q, Wu K, Geng J, Chi S, Wang Y, Zhi P, et al.
Neuron
. 2016 Mar;
89(6):1248-1263.
PMID: 26924440
Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation...
9.
Yuan Q, Deng K, Sun L, Chi S, Yang Z, Wang J, et al.
Sci Rep
. 2016 Feb;
6:21087.
PMID: 26888649
Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which is an intracellular calcium channel and abundant in the brain....
10.
Chi S, Xiao R, Li Q, Zhou L, He R, Qi Z
Pflugers Arch
. 2009 Feb;
458(3):537-45.
PMID: 19198874
Lampreys are one of the most primitive vertebrates still living today. They attach themselves to the body surface of the host fish through their sucker-like mouths and suck blood of...