Shanu Jain
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Explore the profile of Shanu Jain including associated specialties, affiliations and a list of published articles.
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28
Citations
492
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Recent Articles
1.
Jain S, Shukla A
Trends Endocrinol Metab
. 2024 Jun;
35(9):761-762.
PMID: 38945795
In a recent article, Leeson-Payne et al. demonstrate that GPR75 knock-out in mice results in lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity and...
2.
Barella L, Jain S, Pydi S
Front Endocrinol (Lausanne)
. 2022 Aug;
13:984253.
PMID: 35992121
No abstract available.
3.
Jain S, Jacobson K
Curr Opin Pharmacol
. 2022 Mar;
63:102190.
PMID: 35231671
Extracellular uridine nucleotides regulate physiological and pathophysiological metabolic processes through the activation of P2Y, P2Y, P2Y and P2Y purinergic receptors, which play a key role in adipogenesis, glucose uptake, lipolysis...
4.
Salmaso V, Jain S, Jacobson K
Methods Cell Biol
. 2021 Nov;
166:133-159.
PMID: 34752329
We compare the GPCR-ligand interactions and highlight important residues for recognition in purinergic receptors-from both X-ray crystallographic and cryo-EM structures. These include A and A adenosine receptors, and P2Y and...
5.
Jain S, Jacobson K
Front Endocrinol (Lausanne)
. 2021 Aug;
12:718429.
PMID: 34456873
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP....
6.
Jain S, Barella L, Wess J, Reitman M, Jacobson K
Biochem Pharmacol
. 2021 Aug;
192:114739.
PMID: 34418353
Hepatic insulin resistance (IR) and enhanced hepatic glucose production (HGP) are key features of type 2 diabetes (T2D), contributing to fasting hyperglycemia. Adenosine receptors (ARs) are G protein-coupled and expressed...
7.
Barella L, Rossi M, Pydi S, Meister J, Jain S, Cui Y, et al.
Nat Commun
. 2021 Jun;
12(1):3385.
PMID: 34099679
Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion of beta-cell mass is able to...
8.
Oliva P, Scortichini M, Dobelmann C, Jain S, Gopinatth V, Toti K, et al.
Bioorg Med Chem Lett
. 2021 May;
45:128137.
PMID: 34048882
The G-coupled P2Y receptor (P2YR) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2YR agonist and P2YR partial agonist,...
9.
Jain S, Pydi S, Jung Y, Scortichini M, Kesner E, Karcz T, et al.
JCI Insight
. 2021 May;
6(10).
PMID: 34027896
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance,...
10.
Jung Y, Jain S, Gopinatth V, Phung N, Gao Z, Jacobson K
Bioorg Med Chem Lett
. 2021 Apr;
41:128008.
PMID: 33831560
Various 6-alkynyl analogues of a known 3-nitro-2-(trifluoromethyl)-2H-chromene antagonist 3 of the G-coupled P2Y receptor (P2YR) were synthesized using a Sonogashira reaction to replace a 6-iodo group. The analogues were tested...