Shane R Horman
Overview
Explore the profile of Shane R Horman including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
675
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Recent Articles
1.
Yang J, Kulkarni N, Yamaji M, Shiraishi T, Pham T, Do H, et al.
PLoS One
. 2024 Dec;
19(12):e0314227.
PMID: 39700125
Cancer-associated fibroblasts (CAFs) play pivotal roles in solid tumor initiation, growth, and immune evasion. However, the optimal biomimetic modeling conditions remain elusive. In this study, we investigated the effects of...
2.
Yang J, Toughiri R, Gounder A, Scheibe D, Petrus M, Fink S, et al.
PLoS One
. 2024 Nov;
19(11):e0307049.
PMID: 39504332
Induction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies. To identify targets and target-modulating small molecules...
3.
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli
Pai V, Lau C, Garcia-Ruiz A, Donaldson C, Vaughan J, Miller B, et al.
BMC Genomics
. 2024 Nov;
25(1):1034.
PMID: 39497054
Background: Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most...
4.
Yu S, Kalinin A, Paraskevopoulou M, Maruggi M, Cheng J, Tang J, et al.
Cell Chem Biol
. 2023 Jul;
30(9):1169-1182.e8.
PMID: 37437569
Intestinal fibrosis, often caused by inflammatory bowel disease, can lead to intestinal stenosis and obstruction, but there are no approved treatments. Drug discovery has been hindered by the lack of...
5.
Yu S, Ericson M, Fanjul A, Erion D, Paraskevopoulou M, Smith E, et al.
ACS Chem Biol
. 2022 Mar;
17(4):918-929.
PMID: 35274923
Liver fibrosis progression in chronic liver disease leads to cirrhosis, liver failure, or hepatocellular carcinoma and often ends in liver transplantation. Even with an increased understanding of liver fibrogenesis and...
6.
To J, Quackenbush D, Rowell E, Li L, Reed C, Lo F, et al.
Commun Biol
. 2021 Aug;
4(1):1032.
PMID: 34453092
No abstract available.
7.
Grandhi T, To J, Romero A, Luna F, Barnes W, Walker J, et al.
Biotechnol Bioeng
. 2021 May;
118(8):3187-3199.
PMID: 34050941
Cancer is a disease of somatic mutations. These cellular mutations compete to dominate their microenvironment and dictate the disease outcome. While a therapeutic approach to target-specific oncogenic driver mutations helps...
8.
To J, Quackenbush D, Rowell E, Li L, Reed C, Lo F, et al.
Commun Biol
. 2021 Jan;
4(1):56.
PMID: 33420321
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. However, exploratory assays involving immune components are often...
9.
Emilsson V, Ilkov M, Lamb J, Finkel N, Gudmundsson E, Pitts R, et al.
Science
. 2018 Aug;
361(6404):769-773.
PMID: 30072576
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were...
10.
Horman S, To J, Lamb J, Zoll J, Leonetti N, Tu B, et al.
Oncotarget
. 2017 Dec;
8(59):99913-99930.
PMID: 29245949
Recent advances in chemotherapeutics highlight the importance of molecularly-targeted perturbagens. Although these therapies typically address dysregulated cancer cell proteins, there are increasing therapeutic modalities that take into consideration cancer cell-extrinsic...