Shaheen A Farhadi
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Explore the profile of Shaheen A Farhadi including associated specialties, affiliations and a list of published articles.
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12
Citations
84
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Recent Articles
1.
Partain B, Bracho-Sanchez E, Farhadi S, Yarmola E, Keselowsky B, Hudalla G, et al.
Arthritis Res Ther
. 2023 Sep;
25(1):173.
PMID: 37723593
Objective: Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3), where IDO increases...
2.
Partain B, Bracho-Sanchez E, Farhadi S, Yarmola E, Keselowsky B, Hudalla G, et al.
Res Sq
. 2023 May;
PMID: 37131836
: Controlling joint inflammation can improve osteoarthritis (OA) symptoms; however, current treatments often fail to provide long-term effects. We have developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3). IDO...
3.
Bracho-Sanchez E, Rocha F, Bedingfield S, Partain B, Macias S, Brusko M, et al.
Nat Biomed Eng
. 2023 May;
7(9):1156-1169.
PMID: 37127708
The treatment of chronic inflammation with systemically administered anti-inflammatory treatments is associated with moderate-to-severe side effects, and the efficacy of locally administered drugs is short-lived. Here we show that inflammation...
4.
Farhadi S, Restuccia A, Sorrentino A, Cruz-Sanchez A, Hudalla G
Mol Syst Des Eng
. 2022 May;
7(1):44-57.
PMID: 35495737
In nature, the precise heterogeneous co-assembly of different protein domains gives rise to supramolecular machines that perform complex functions through the co-integrated activity of the individual protein subunits. A synthetic...
5.
Pineiro-Llanes J, Rodriguez C, Farhadi S, Hudalla G, Sarntinoranont M, Simmons C
Ann Biomed Eng
. 2022 Mar;
50(6):703-715.
PMID: 35352215
Altered extracellular matrix (ECM) production is a hallmark of many fibroproliferative diseases, including certain cancers. The high incidence of glycan-rich components within altered ECM makes the use of glycan-binding proteins...
6.
Kane B, Fettis M, Farhadi S, Liu R, Hudalla G
Cell Mol Bioeng
. 2021 Nov;
14(5):523-534.
PMID: 34777608
Introduction: The promise of the natural immunoregulator, Galectin-1 (Gal1), as an immunomodulatory therapeutic is challenged by its unstable homodimeric conformation. Previously, a Gal1 homodimer stabilized via covalent poly(ethylene glycol) diacrylate...
7.
Farhadi S, Liu R, Becker M, Phelps E, Hudalla G
Proc Natl Acad Sci U S A
. 2021 May;
118(19).
PMID: 33941700
Galectin-3 (Gal3) exhibits dynamic oligomerization and promiscuous binding, which can lead to concomitant activation of synergistic, antagonistic, or noncooperative signaling pathways that alter cell behavior. Conferring signaling pathway selectivity through...
8.
Farhadi S, Fettis M, Liu R, Hudalla G
Front Chem
. 2020 Jan;
7:898.
PMID: 31998689
Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with two G1 and two G3 domains ("G1/G3...
9.
Fettis M, Farhadi S, Hudalla G
Biomater Sci
. 2019 Mar;
7(5):1852-1862.
PMID: 30899922
Galectins are attractive therapeutic candidates to control aberrant immune system activation because they can alter the phenotype and function of various innate and adaptive immune cells. However, use of exogenous...
10.
Farhadi S, Bracho-Sanchez E, Fettis M, Seroski D, Freeman S, Restuccia A, et al.
Nat Commun
. 2018 Nov;
9(1):4943.
PMID: 30467349
Success of enzymes as drugs requires that they persist within target tissues over therapeutically effective time frames. Here we report a general strategy to anchor enzymes at injection sites via...