Shahanas Chathoth
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Explore the profile of Shahanas Chathoth including associated specialties, affiliations and a list of published articles.
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35
Citations
297
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Recent Articles
21.
Vatte C, Cyrus C, Al Shehri A, Chathoth S, Almansori M, Al-Nafaie A, et al.
Ann Saudi Med
. 2016 Mar;
36(2):105-11.
PMID: 26997531
Background: Kinesin-like protein 6 (KIF6), a member of the kinesin superfamily, is involved in intracellular transport. A few prospective studies have shown the KIF6 variant Trp719Arg (rs20455) to be associated...
22.
Cyrus C, Vatte C, Al-Nafie A, Chathoth S, Al-Ali R, Al-Shehri A, et al.
Hum Genomics
. 2016 Mar;
10:8.
PMID: 26936456
Background: Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Many genetic and environmental risk factors including atherogenic dyslipidemia contribute towards the development of CAD. Functionally...
23.
Al-Amri A, Vatte C, Cyrus C, Chathoth S, Hashim T, Mohamed Y, et al.
Cancer Biomark
. 2016 Feb;
16(3):377-83.
PMID: 26889984
Background: HNSCC is the sixth most common human cancer globally. In Saudi Arabia, HNSCC accounts for seven percent of all newly diagnosed cancer cases. The PIK3CA is one of the...
24.
Al-Habdan I, Sadat-Ali M, Safar Alghamdy M, Randhawa A, Chathoth S
Int J Biomed Sci
. 2014 Oct;
10(3):167-71.
PMID: 25324697
Background: Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) was discovered and patented with USPTO in 2008. Studies have shown that SHMSP works as an angiogenesis factor. This study was done to evaluate...
25.
Chathoth S, Thayyullathil F, Galadari A, Patel M, Galadari S
Int J Biochem Mol Biol
. 2013 May;
4(1):54-66.
PMID: 23638321
Ceramidases cleave the N-acyl linkages of ceramide to generate sphingosine and its subsequent product sphingosine-1-phosphate (S1P). Ceramide and S1P are important bioactive lipids, and ceramidases are important in regulating the...
26.
Thayyullathil F, Pallichankandy S, Rahman A, Kizhakkayil J, Chathoth S, Patel M, et al.
J Mol Signal
. 2013 Feb;
8(1):2.
PMID: 23442976
Background: Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-4...
27.
Kizhakkayil J, Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S
Free Radic Biol Med
. 2012 Mar;
52(9):1854-64.
PMID: 22387197
Depletion of intracellular glutathione (GSH) is the prime hallmark of the progression of apoptosis. Previously, we reported that curcumin induces reactive oxygen species (ROS)-mediated depletion of GSH, which leads to...
28.
Thayyullathil F, Chathoth S, Kizhakkayil J, Galadari A, Hago A, Patel M, et al.
Biochem Biophys Res Commun
. 2011 Jun;
411(1):1-6.
PMID: 21669188
Glutathione (GSH) is the most abundant non-protein antioxidant in mammalian cells. It has been implicated in playing an important role in different signal transduction pathways, and its depletion is an...
29.
Thayyullathil F, Chathoth S, Shahin A, Kizhakkayil J, Hago A, Patel M, et al.
J Cell Biochem
. 2011 Feb;
112(4):1138-53.
PMID: 21308747
Sphingosine (SPH) is an important bioactive lipid involved in mediating a variety of cell functions including apoptosis. However, the signaling mechanism of SPH-induced apoptosis remains unclear. We have investigated whether...
30.
Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc Z, Hannun Y, et al.
Biochim Biophys Acta
. 2011 Jan;
1811(4):242-52.
PMID: 21224012
Ceramidases (CDase) are enzymes that catalyze the hydrolysis of N-acyl linkage of ceramide (Cer) to generate sphingosine and free fatty acids. In this study we report the purification and characterization...