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Severine Bontron

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Articles 19
Citations 988
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Recent Articles
1.
Bontron S, Poirel L, Kieffer N, Savov E, Trifonova A, Todorova I, et al.
Microb Drug Resist . 2019 Jan; 25(5):663-667. PMID: 30676261
The aim of the study was to decipher the mechanisms and associated genetic determinants responsible for increased carbapenem resistance among clinical isolates. The entire genetic structure surrounding the β-lactam resistance...
2.
Bontron S, Nordmann P, Poirel L
Antimicrob Agents Chemother . 2016 Sep; 60(12):7245-7251. PMID: 27671058
The bla gene encodes a carbapenemase that confers resistance to almost all β-lactams, including last-resort carbapenems. This is increasingly reported worldwide in nosocomial and community-acquired Gram-negative bacteria. Acinetobacter baumannii is...
3.
Bontron S, Poirel L, Nordmann P
J Antimicrob Chemother . 2016 Apr; 71(8):2318-20. PMID: 27121402
Objectives: The aim of the study was to develop a simple assay for rapid detection of the mcr-1 gene, recently identified as a source of plasmid-mediated acquired resistance to polymyxins...
4.
Krahn T, Wibberg D, Maus I, Winkler A, Bontron S, Sczyrba A, et al.
Antimicrob Agents Chemother . 2016 Mar; 60(5):3032-40. PMID: 26953198
The species Acinetobacter baumannii is one of the most important multidrug-resistant human pathogens. To determine its virulence and antibiotic resistance determinants, the genome of the nosocomial blaNDM-1-positive A. baumannii strain...
5.
Bontron S, Poirel L, Nordmann P
Antimicrob Agents Chemother . 2015 Jan; 59(3):1664-70. PMID: 25561336
Resistance to β-lactams is constantly increasing due to the emergence of totally new enzymes but also to the evolution of preexisting β-lactamases. GES-1 is a clinically relevant extended-spectrum β-lactamase (ESBL)...
6.
Poirel L, Jayol A, Bontron S, Villegas M, Ozdamar M, Turkoglu S, et al.
J Antimicrob Chemother . 2014 Sep; 70(1):75-80. PMID: 25190723
Objectives: Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling...
7.
Dubots E, Cottier S, Peli-Gulli M, Jaquenoud M, Bontron S, Schneiter R, et al.
PLoS One . 2014 Aug; 9(8):e104194. PMID: 25117580
The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls growth-related processes such as protein, nucleotide, and lipid metabolism in response to growth hormones, energy/ATP levels, and amino acids. Its...
8.
Talarek N, Bontron S, De Virgilio C
RNA Biol . 2013 Jun; 10(8):1299-308. PMID: 23792549
Eukaryotic cells rapidly adjust the levels of mRNAs in response to environmental stress primarily by controlling transcription and mRNA turnover. How different stress conditions influence the fate of stress-responsive mRNAs,...
9.
Bontron S, Jaquenoud M, Vaga S, Talarek N, Bodenmiller B, Aebersold R, et al.
Cell Rep . 2013 Jan; 3(1):16-22. PMID: 23273919
The TORC1 and PKA protein kinases are central elements of signaling networks that regulate eukaryotic cell proliferation in response to growth factors and/or nutrients. In yeast, attenuation of signaling by...
10.
Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C, De Virgilio C
Mol Cell . 2012 Mar; 46(1):105-10. PMID: 22424774
The target of rapamycin complex 1 (TORC1) is an essential regulator of eukaryotic cell growth that responds to growth factors, energy levels, and amino acids. The mechanisms through which the...