Seung Seo Lee
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Explore the profile of Seung Seo Lee including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
23
Citations
452
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0
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Recent Articles
11.
Bilyard M, Bailey H, Raich L, Gafitescu M, Machida T, Iglesias-Fernandez J, et al.
Nature
. 2018 Oct;
563(7730):235-240.
PMID: 30356213
Biosynthesis of glycogen, the essential glucose (and hence energy) storage molecule in humans, animals and fungi, is initiated by the glycosyltransferase enzyme, glycogenin (GYG). Deficiencies in glycogen formation cause neurodegenerative...
12.
Iglesias-Fernandez J, Hancock S, Lee S, Khan M, Kirkpatrick J, Oldham N, et al.
Nat Chem Biol
. 2017 Jun;
13(8):874-881.
PMID: 28604696
Si-like mechanisms, which involve front-face leaving group departure and nucleophile approach, have been observed experimentally and computationally in chemical and enzymatic substitution at α-glycosyl electrophiles. Since Si-like, S1 and S2...
13.
Perez-Balderas F, van Kasteren S, Aljabali A, Wals K, Serres S, Jefferson A, et al.
Nat Commun
. 2017 Feb;
8:14254.
PMID: 28198362
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in...
14.
Nguyen T, Ho M, Ghosh A, Kim T, Yun S, Lee S, et al.
Biochem Biophys Res Commun
. 2016 Sep;
479(1):33-9.
PMID: 27613091
The ubiquitin pathway plays a critical role in regulating diverse biological processes, and its dysregulation is associated with various diseases. Therefore, it is important to have a tool that can...
15.
Wyszynski F, Lee S, Yabe T, Wang H, Gomez-Escribano J, Bibb M, et al.
Nat Chem
. 2012 Jun;
4(7):539-46.
PMID: 22717438
The tunicamycins are archetypal nucleoside antibiotics targeting bacterial peptidoglycan biosynthesis and eukaryotic protein N-glycosylation. Understanding the biosynthesis of their unusual carbon framework may lead to variants with improved selectivity. Here,...
16.
Lee S, Greig I, Vocadlo D, McCarter J, Patrick B, Withers S
J Am Chem Soc
. 2011 Sep;
133(40):15826-9.
PMID: 21910446
The effects of fluorine substitution at the C-5 center of pyranosyl fluorides on the reactivity at the C-1 anomeric center was probed by studying a series of 5-fluoroxylosyl fluoride derivatives....
17.
Lee S, Hong S, Errey J, Izumi A, Davies G, Davis B
Nat Chem Biol
. 2011 Aug;
7(9):631-8.
PMID: 21822275
A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state-like arrangement based on validoxylamine A 6'-O-phosphate and uridine diphosphate in the active site....
18.
Backus K, Boshoff H, Barry C, Boutureira O, Patel M, DHooge F, et al.
Nat Chem Biol
. 2011 Mar;
7(4):228-35.
PMID: 21378984
The detection of tuberculosis currently relies upon insensitive and unspecific techniques; newer diagnostics would ideally co-opt specific bacterial processes to provide real-time readouts. The trehalose mycolyltransesterase enzymes (antigens 85A, 85B...
19.
Errey J, Lee S, Gibson R, Fleites C, Barry C, Jung P, et al.
Angew Chem Int Ed Engl
. 2010 Jan;
49(7):1234-7.
PMID: 20077550
No abstract available.
20.
Lovering A, Lee S, Kim Y, Withers S, Strynadka N
J Biol Chem
. 2004 Oct;
280(3):2105-15.
PMID: 15501829
We have determined the first structure of a family 31 alpha-glycosidase, that of YicI from Escherichia coli, both free and trapped as a 5-fluoroxylopyranosyl-enzyme intermediate via reaction with 5-fluoro-alpha-D-xylopyranosyl fluoride....